Evidence map›Paper›PMID 41492998›Full record

ArticleJournal of enzyme inhibition and medicinal chemistry2026

Imidazole-2-thione derivatives as new selective anticancer agents with anti-metastatic properties: synthesis and pharmacological evaluation.

Božena Golcienė, Natalia Maciejewska, Anoop Kallingal, Birutė Sapijanskaitė-Banevič, Maryna Stasevych, Vytautas Mickevičius

Abstract read
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In one paragraph

Article in Journal of enzyme inhibition and medicinal chemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Božena GolcienėDepartment of Organic Chemistry, Kaunas University of Technology, Kaunas, Lithuania.
Natalia MaciejewskaDepartment of Pharmaceutical Technology and Biochemistry, Faculty of Chemistry, Gdansk University of Technology, Gdansk, Poland.ORCID 0000-0001-9942-285X
Anoop KallingalDepartment of Pharmaceutical Technology and Biochemistry, Faculty of Chemistry, Gdansk University of Technology, Gdansk, Poland.
Birutė Sapijanskaitė-BanevičDepartment of Organic Chemistry, Kaunas University of Technology, Kaunas, Lithuania.ORCID 0000-0001-9090-9127
Maryna StasevychDepartment of Technology of Biologically Active Substances, Pharmacy and Biotechnology, Lviv Polytechnic National University, Lviv, Ukraine.ORCID 0000-0001-5042-4133
Vytautas MickevičiusDepartment of Organic Chemistry, Kaunas University of Technology, Kaunas, Lithuania.ORCID 0000-0002-9961-2941

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Imidazole scaffolds are attractive in drug design for bioactivity and synthetic accessibility. We developed S-substituted imidazole-2-thione derivatives, focusing on compound

Indexed as

Antineoplastic AgentsImidazolesThionesAnimalsApoptosisCell Line, TumorCell MovementCell ProliferationDose-Response Relationship, DrugDrug Screening Assays, AntitumorHumansMatrix Metalloproteinase 9MiceMolecular StructureStructure-Activity RelationshipAntineoplastic AgentsImidazolesMatrix Metalloproteinase 9Thionesanticanceranti-metastaticImidazole-2-thionelung cancerMMPs

Identifiers

PMID41492998
PMCPMC12777803

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.