Evidence map›Paper›PMID 41492994›Full record

ArticleJournal of enzyme inhibition and medicinal chemistry2026

Identification of the first peptide inhibitor of UBE2C enzymatic activity: insights from metadynamics-guided folding and binding studies.

Luciano Pirone, Bianca Fiorillo, Annarita Del Gatto, Rita Russo, Alessandra Guarracino, Chiara Cassiano, Laura Zaccaro, Federica Moraca, Emilia Pedone, Bruno Catalanotti

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Article in Journal of enzyme inhibition and medicinal chemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Luciano PironeInstitute of Biostructures and Bioimaging, Naples, Italy.
Bianca FiorilloDepartment of Pharmacy, University of Naples "Federico II", Naples, Italy.
Annarita Del GattoInstitute of Biostructures and Bioimaging, Naples, Italy.
Rita RussoInstitute of Biostructures and Bioimaging, Naples, Italy.
Alessandra GuarracinoDepartment of Pharmacy, University of Naples "Federico II", Naples, Italy.
Chiara CassianoDepartment of Pharmacy, University of Naples "Federico II", Naples, Italy.
Laura ZaccaroInstitute of Biostructures and Bioimaging, Naples, Italy.
Federica MoracaDepartment of Pharmacy, University of Naples "Federico II", Naples, Italy.
Emilia PedoneInstitute of Biostructures and Bioimaging, Naples, Italy.
Bruno CatalanottiDepartment of Pharmacy, University of Naples "Federico II", Naples, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

UBE2C (also known as UbcH10) is a ubiquitin-conjugating enzyme essential for mitotic progression and a potential therapeutic target in cancer. Here, we report a structure-based design and characterisation of peptides derived from a natural interacting partner (U1) aimed at modulating UBE2C activity. Biophysical and biochemical assays identified peptide

Indexed as

Enzyme InhibitorsPeptidesUbiquitin-Conjugating EnzymesDose-Response Relationship, DrugHumansMolecular Dynamics SimulationMolecular StructureProtein FoldingStructure-Activity RelationshipEnzyme InhibitorsPeptidesUBE2C protein, humanUbiquitin-Conjugating Enzymescancermetadynamicspeptide-protein interactionUBE2CUbiquitin conjugation enzymes

Identifiers

PMID41492994
PMCPMC12777749

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.