Evidence map›Paper›PMID 41492732›Full record

ArticleOral diseases2026

The Role of the Oral Microbiome in Circulating Metabolic Biomarkers and the Influence of Air Pollution.

Jiajun Luo, Yuqing Wu, Habibul Ahsan, Christopher O Olopade, Jayant M Pinto, Briseis Aschebrook-Kilfoy

Abstract read
In one paragraph

Article in Oral diseases, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Jiajun LuoDepartment of Public Health and Medicinal Administration, Faculty of Health Sciences, University of Macau, Macao SAR, China.ORCID https://orcid.org/0000-0002-5335-879X
Yuqing WuInstitute for Population and Precision Health, The University of Chicago, Biological Science Division, Chicago, Illinois, USA.
Habibul AhsanInstitute for Population and Precision Health, The University of Chicago, Biological Science Division, Chicago, Illinois, USA.
Christopher O OlopadeDepartment of Family Medicine, The University of Chicago Biological Science Division, Chicago, Illinois, USA.
Jayant M PintoDepartment of Surgery, The University of Chicago Biological Science Division, Chicago, Illinois, USA.
Briseis Aschebrook-KilfoyInstitute for Population and Precision Health, The University of Chicago, Biological Science Division, Chicago, Illinois, USA.

Funding

Pilot Program CoreP30ES027792 · NIEHS · UNIVERSITY OF CHICAGO · PI Gokhan M. Mutlu, Gail S Prins · 2017 to 2026
$13.6M
NIEHSNIEHS NIH HHS P30 ES027792NIH HHS
6 · The paper itself

Abstract

aimsThe oral microbiome is at the frontline for environmental exposure and plays an important role in human metabolism. This study explores the relationship between PM

methodsData from 473 adult participants (97.7% Black; median age: 53.6) were analyzed. PM

resultsA total of 20 oral microbiome taxa were significantly associated with at least one biomarker, with genus Atopobium linked to all three. Insulin demonstrated the strongest sensitivity to the oral microbiome influence. Genera in phyla Actinomycetota and Bacillota played key roles in the relationship between the oral microbiome and metabolic biomarkers. Mediation analysis revealed that the oral microbiome mediated 16.5% and 11.1% of PM

conclusionThis study suggests potential mechanisms regarding how the oral microbiome influences metabolic biomarkers and mediates the metabolic effects of PM

Indexed as

Air PollutionEnvironmental ExposureInsulinMicrobiotaMouthParticulate MatterAdultBiomarkersFemaleGhrelinHumansMaleMiddle AgedResistinRetrospective StudiesSalivaBiomarkersGhrelinInsulinParticulate MatterResistinair pollutioninsulinoral microbiome

Identifiers

PMID41492732
PMCPMC13034858

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.