ArticleAnnals of medicine2026
Long-term outcomes after treatment for symptomatic hemorrhage of brain arteriovenous malformations.
Article in Annals of medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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7 authors.
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Abstract
objectivesTo determine the long-term risk factors for rehemorrhage (primary outcome) in patients with ruptured brain arteriovenous malformations (BAVMs) after different treatment strategies and to evaluate the impact of different treatment strategies on lesion obliteration (secondary outcome) over a 10-year follow-up.
methodsThis single-center retrospective cohort included 645 patients with ruptured brain arteriovenous malformations (BAVMs) treated between 2010 and 2019, with a median follow-up of 96 months. Patients were randomly divided into training (70%) and validation (30%) cohorts to identify and validate predictors of rehemorrhage-free survival (RFS). Cox regression analyses were performed to assess risk factors for RFS, while logistic regression and propensity score matching (PSM) were used to evaluate the impact of treatment strategies on obliteration and rehemorrhage.
resultsObliteration was observed in 66.0% (384/582) of the patients, and 109 patients (16.9%) experienced rehemorrhage. In the training set, the multivariate Cox regression analysis revealed that, deep location ((hazard ratio (HR) = 2.033, 95% confidence interval (CI) = 1.166-3.545;
conclusionsLesion size, lesion location, and multiple draining veins were independently associated with long-term RFS. Preradiosurgical embolization improved the obliteration rate but did not significantly alter the risk of rehemorrhage. These findings directly inform treatment selection for ruptured BAVMs.
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