Evidence map›Paper›PMID 41492646›Full record

ArticleMaterials today. Bio2026

Mechano-matching hydrogel patch promotes myocardial infarction repair via YAP-Bcl-2 pathway activation.

Yanyan Zhao, Jie Shen, Rurong Lin, Jianxing Huang, Xiaoming Zou, Honghao Hou, Xiaozhong Qiu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Materials today. Bio, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Yanyan ZhaoThe Seventh Affiliated Hospital, Southern Medical University, Foshan, 528244, Guangdong, PR China.
Jie ShenGuangdong Provincial Key Laboratory of Construction and Detection in Tissue Engineering, School of Basic Medical Sciences, Southern Medical University, Guangzhou, 510515, Guangdong, PR China.
Rurong LinGuangdong Provincial Key Laboratory of Construction and Detection in Tissue Engineering, School of Basic Medical Sciences, Southern Medical University, Guangzhou, 510515, Guangdong, PR China.
Jianxing HuangGuangdong Provincial Key Laboratory of Construction and Detection in Tissue Engineering, School of Basic Medical Sciences, Southern Medical University, Guangzhou, 510515, Guangdong, PR China.
Xiaoming ZouThe Seventh Affiliated Hospital, Southern Medical University, Foshan, 528244, Guangdong, PR China.
Honghao HouGuangdong Provincial Key Laboratory of Construction and Detection in Tissue Engineering, School of Basic Medical Sciences, Southern Medical University, Guangzhou, 510515, Guangdong, PR China.
Xiaozhong QiuInternational Center for Translational Medicine, Shunde Hospital, Southern Medical University, Foshan, 528300, Guangdong, PR China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Although elastic cardiac patches have demonstrated efficacy in alleviating ventricular wall stress and restoring cardiac function following myocardial infarction (MI), the mechanistic basis governing their therapeutic effects remains incompletely elucidated. In this study, three distinct acellular hydrogel patches with tailored elastic moduli were fabricated, namely soft (1.61 kPa), mechano-matching (16.82 kPa, corresponding to the moduli of native adult myocardium), and rigid (602.61 kPa). These patches were implanted in a rat model of MI to evaluate their therapeutic potential. Among the three groups, the mechano-matching hydrogel patch exhibited superior performance, significantly improving cardiac function (with left ventricular ejection fraction [LVEF] elevated by 15.89 %,

Indexed as

Elastic hydrogel patchHippo-YAP pathwayMechanotransductionMyocardial infarction

Identifiers

PMID41492646
PMCPMC12765076

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.