Evidence map›Paper›PMID 41492472›Full record

ArticleGenes & diseases2026

Macrophage κ-opioid receptor inhibits hypoxic pulmonary hypertension progression and right heart dysfunction via an SCD1-dependent anti-inflammatory response.

Qiaojuan Wang, Jiayuan Liu, Renqi Li, Sihan Kong, Yinjie Wang, Guoyang Huang, Shumiao Zhang, Na Feng, Xiaoming Gu, Yali Liu and 5 more

Abstract read
In one paragraph

Article in Genes & diseases, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Qiaojuan WangDepartment of Physiology and Pathophysiology, National Key Discipline of Cell Biology, Fourth Military Medical University, No. 169 Changle West Road, Xi'an, Shaanxi 710032, China.
Jiayuan LiuDepartment of Physiology and Pathophysiology, National Key Discipline of Cell Biology, Fourth Military Medical University, No. 169 Changle West Road, Xi'an, Shaanxi 710032, China.
Renqi LiDepartment of Physiology and Pathophysiology, National Key Discipline of Cell Biology, Fourth Military Medical University, No. 169 Changle West Road, Xi'an, Shaanxi 710032, China.
Sihan KongDepartment of Physiology and Pathophysiology, National Key Discipline of Cell Biology, Fourth Military Medical University, No. 169 Changle West Road, Xi'an, Shaanxi 710032, China.
Yinjie WangDepartment of Physiology and Pathophysiology, National Key Discipline of Cell Biology, Fourth Military Medical University, No. 169 Changle West Road, Xi'an, Shaanxi 710032, China.
Guoyang HuangDepartment of Physiology and Pathophysiology, National Key Discipline of Cell Biology, Fourth Military Medical University, No. 169 Changle West Road, Xi'an, Shaanxi 710032, China.
Shumiao ZhangDepartment of Physiology and Pathophysiology, National Key Discipline of Cell Biology, Fourth Military Medical University, No. 169 Changle West Road, Xi'an, Shaanxi 710032, China.
Na FengDepartment of Physiology and Pathophysiology, National Key Discipline of Cell Biology, Fourth Military Medical University, No. 169 Changle West Road, Xi'an, Shaanxi 710032, China.
Xiaoming GuDepartment of Physiology and Pathophysiology, National Key Discipline of Cell Biology, Fourth Military Medical University, No. 169 Changle West Road, Xi'an, Shaanxi 710032, China.
Yali LiuDepartment of Physiology and Pathophysiology, National Key Discipline of Cell Biology, Fourth Military Medical University, No. 169 Changle West Road, Xi'an, Shaanxi 710032, China.
Ming JiaDepartment of Physiology and Pathophysiology, National Key Discipline of Cell Biology, Fourth Military Medical University, No. 169 Changle West Road, Xi'an, Shaanxi 710032, China.
Feng FuDepartment of Physiology and Pathophysiology, National Key Discipline of Cell Biology, Fourth Military Medical University, No. 169 Changle West Road, Xi'an, Shaanxi 710032, China.
Jun LiDepartment of Physiology and Pathophysiology, National Key Discipline of Cell Biology, Fourth Military Medical University, No. 169 Changle West Road, Xi'an, Shaanxi 710032, China.
Juan LiDepartment of Physiology and Pathophysiology, National Key Discipline of Cell Biology, Fourth Military Medical University, No. 169 Changle West Road, Xi'an, Shaanxi 710032, China.
Jianming PeiDepartment of Physiology and Pathophysiology, National Key Discipline of Cell Biology, Fourth Military Medical University, No. 169 Changle West Road, Xi'an, Shaanxi 710032, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We aimed to investigate the effects and mechanism(s) of macrophage κ-opioid receptor (κ-OR) on macrophage inflammatory response and hypoxic pulmonary hypertension (HPH). Macrophage κ-OR-deficient mice (κ-OR

Indexed as

Hypoxic pulmonary hypertensionInflammationMacrophageSCD1κ-opioid receptor

Identifiers

PMID41492472
PMCPMC12765096

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.