Evidence map›Paper›PMID 41492461›Full record

ArticleJournal of pharmaceutical analysis2025

1,8-Cineole ameliorates vascular endothelial senescence in diabetes mellitus by directly targeting and deubiquitinating PPAR-γ

Lingyun Fu, Shidie Tai, Jiajia Liao, Youqi Du, Guangqiong Zhang, Die Guo, Xingmei Chen, Tian Zheng, Xiaoxia Hu, Wenbing Yao and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of pharmaceutical analysis, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Lingyun FuThe State Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Medical University, Guiyang, 561113, China.
Shidie TaiThe State Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Medical University, Guiyang, 561113, China.
Jiajia LiaoThe State Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Medical University, Guiyang, 561113, China.
Youqi DuThe State Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Medical University, Guiyang, 561113, China.
Guangqiong ZhangThe State Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Medical University, Guiyang, 561113, China.
Die GuoThe State Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Medical University, Guiyang, 561113, China.
Xingmei ChenThe State Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Medical University, Guiyang, 561113, China.
Tian ZhengThe State Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Medical University, Guiyang, 561113, China.
Xiaoxia HuThe State Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Medical University, Guiyang, 561113, China.
Wenbing YaoThe State Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Medical University, Guiyang, 561113, China.
Ling TaoThe State Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Medical University, Guiyang, 561113, China.
Xueting WangThe State Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Medical University, Guiyang, 561113, China.
Yini XuThe State Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Medical University, Guiyang, 561113, China.
Xiangchun ShenThe State Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Medical University, Guiyang, 561113, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Vascular endothelial senescence is an important pathophysiological factor in the development and exacerbation of cardiovascular health problems linked to diabetes mellitus (DM). Accumulating evidence confirms that 1,8-cineole has multiple pharmacological properties, including anti-inflammatory, anti-microbial, and antioxidant activities. We investigated whether 1,8-cineole could ameliorate cardiovascular diseases and endothelial dysfunction, as the pharmacological properties and mechanism of diabetic vascular ageing remain unknown. Our results revealed notable senescence biomarkers in both

Indexed as

1,8-CineolePeroxisome proliferator-activated receptor-γUbiquitinationVascular endothelial cell senescence

Identifiers

PMID41492461
PMCPMC12765251

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.