Evidence map›Paper›PMID 41492404›Full record

ArticleAlzheimer's & dementia (Amsterdam, Netherlands)

The relationship between cognitive screeners and everyday functioning in amyloid-positive participants from the Amsterdam Dementia Cohort.

Angela van der Putten-Toorenburg, Elke Butterbrod, Benjamin D Schalet, Pieter J van der Veere, Mukrabe E Tewolde, Merel C Postema, Elsmarieke van de Giessen, Charlotte E Teunissen, Argonde C van Harten, Wiesje M van der Flier and 1 more

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Article in Alzheimer's & dementia (Amsterdam, Netherlands). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Angela van der Putten-ToorenburgFaculty of Behavioural and Movement Sciences Department of Clinical Neuro- and Developmental Psychology Vrije Universiteit Amsterdam Amsterdam The Netherlands.ORCID https://orcid.org/0009-0003-2649-2349
Elke ButterbrodFaculty of Behavioural and Movement Sciences Department of Clinical Neuro- and Developmental Psychology Vrije Universiteit Amsterdam Amsterdam The Netherlands.
Benjamin D SchaletDepartment of Epidemiology and Data Science Vrije Universiteit Amsterdam Amsterdam UMC Amsterdam The Netherlands.
Pieter J van der VeereAlzheimer Center Amsterdam Department of Neurology Vrije Universiteit Amsterdam Amsterdam UMC location VUmc Amsterdam The Netherlands.
Mukrabe E TewoldeAlzheimer Center Amsterdam Department of Neurology Vrije Universiteit Amsterdam Amsterdam UMC location VUmc Amsterdam The Netherlands.
Merel C PostemaAlzheimer Center Amsterdam Department of Neurology Vrije Universiteit Amsterdam Amsterdam UMC location VUmc Amsterdam The Netherlands.
Elsmarieke van de GiessenAmsterdam Neuroscience-Neurodegeneration Vrije Universiteit Amsterdam Amsterdam The Netherlands.
Charlotte E TeunissenAmsterdam Neuroscience-Neurodegeneration Vrije Universiteit Amsterdam Amsterdam The Netherlands.
Argonde C van HartenAlzheimer Center Amsterdam Department of Neurology Vrije Universiteit Amsterdam Amsterdam UMC location VUmc Amsterdam The Netherlands.
Wiesje M van der FlierAlzheimer Center Amsterdam Department of Neurology Vrije Universiteit Amsterdam Amsterdam UMC location VUmc Amsterdam The Netherlands.
Sietske A M SikkesFaculty of Behavioural and Movement Sciences Department of Clinical Neuro- and Developmental Psychology Vrije Universiteit Amsterdam Amsterdam The Netherlands.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionWe explored the relationship between cognitive screening outcomes and everyday functioning in Alzheimer's disease (AD).

methodsA total of 1228 amyloid-positive participants were included from the Amsterdam Dementia Cohort. Multiple linear regression analyses assessed the relationship between Mini-Mental State Examination (MMSE), Montreal Cognitive Assessment (MoCA), and everyday functioning (Amsterdam Instrumental Activities of Daily Living Questionnaire [A-IADL-Q-30]). To link cognitive screeners to functional impairment, we described difficulties across A-IADL-Q-30 items by MMSE and MoCA quartiles.

resultsBoth MMSE ( DISCUSSION: In amyloid-positive participants, the association between cognition and daily functioning was moderate, reinforcing the importance of assessing both constructs in disease monitoring. Highlights: Cognitive screening tools were moderately associated with daily functioning.Difficulties in complex daily tasks were present in the higher cognitive performance quartiles.Findings suggest that combining cognition and function is required for disease monitoring.

Indexed as

Alzheimer's diseaseclinical meaningfulnesseveryday functioningglobal cognitioninstrumental activities of daily livingpreclinical AD

Identifiers

PMID41492404
PMCPMC12765400

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.