Evidence map›Paper›PMID 41492368›Full record

ArticleBioactive materials2026

Engineered polypeptide cascade-release platform restores macrophage plasticity for accelerated diabetic wound healing.

Hao Xia, Qi Tang, Zhen Chen, Shujun Cao, Lihuang Wu, Lili Hao, Xiulan Hu, Lingyun Sun, Zhongwei Gu, Hongli Mao

Abstract read
In one paragraph

Article in Bioactive materials, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Hao XiaResearch Institute for Biomaterials, Tech Institute for Advanced Materials, Bio-inspired Biomedical Materials & Devices Center, College of Materials Science and Engineering, Jiangsu Collaborative Innovation Center for Advanced Inorganic Function Composites, Suqian Advanced Materials Industry Technology Innovation Center, Nanjing Tech University, Nanjing, 211816, China.
Qi TangResearch Institute for Biomaterials, Tech Institute for Advanced Materials, Bio-inspired Biomedical Materials & Devices Center, College of Materials Science and Engineering, Jiangsu Collaborative Innovation Center for Advanced Inorganic Function Composites, Suqian Advanced Materials Industry Technology Innovation Center, Nanjing Tech University, Nanjing, 211816, China.
Zhen ChenResearch Institute for Biomaterials, Tech Institute for Advanced Materials, Bio-inspired Biomedical Materials & Devices Center, College of Materials Science and Engineering, Jiangsu Collaborative Innovation Center for Advanced Inorganic Function Composites, Suqian Advanced Materials Industry Technology Innovation Center, Nanjing Tech University, Nanjing, 211816, China.
Shujun CaoResearch Institute for Biomaterials, Tech Institute for Advanced Materials, Bio-inspired Biomedical Materials & Devices Center, College of Materials Science and Engineering, Jiangsu Collaborative Innovation Center for Advanced Inorganic Function Composites, Suqian Advanced Materials Industry Technology Innovation Center, Nanjing Tech University, Nanjing, 211816, China.
Lihuang WuResearch Institute for Biomaterials, Tech Institute for Advanced Materials, Bio-inspired Biomedical Materials & Devices Center, College of Materials Science and Engineering, Jiangsu Collaborative Innovation Center for Advanced Inorganic Function Composites, Suqian Advanced Materials Industry Technology Innovation Center, Nanjing Tech University, Nanjing, 211816, China.
Lili HaoResearch Institute for Biomaterials, Tech Institute for Advanced Materials, Bio-inspired Biomedical Materials & Devices Center, College of Materials Science and Engineering, Jiangsu Collaborative Innovation Center for Advanced Inorganic Function Composites, Suqian Advanced Materials Industry Technology Innovation Center, Nanjing Tech University, Nanjing, 211816, China.
Xiulan HuResearch Institute for Biomaterials, Tech Institute for Advanced Materials, Bio-inspired Biomedical Materials & Devices Center, College of Materials Science and Engineering, Jiangsu Collaborative Innovation Center for Advanced Inorganic Function Composites, Suqian Advanced Materials Industry Technology Innovation Center, Nanjing Tech University, Nanjing, 211816, China.
Lingyun SunDepartment of Rheumatology and Immunology, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, 210008, China.
Zhongwei GuResearch Institute for Biomaterials, Tech Institute for Advanced Materials, Bio-inspired Biomedical Materials & Devices Center, College of Materials Science and Engineering, Jiangsu Collaborative Innovation Center for Advanced Inorganic Function Composites, Suqian Advanced Materials Industry Technology Innovation Center, Nanjing Tech University, Nanjing, 211816, China.
Hongli MaoResearch Institute for Biomaterials, Tech Institute for Advanced Materials, Bio-inspired Biomedical Materials & Devices Center, College of Materials Science and Engineering, Jiangsu Collaborative Innovation Center for Advanced Inorganic Function Composites, Suqian Advanced Materials Industry Technology Innovation Center, Nanjing Tech University, Nanjing, 211816, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Persistent inflammatory episodes driven by immune cell dysregulation pose a formidable clinical challenge in diabetic wound healing. Sustained and coordinated regulation of the immune niche within diabetic wounds is critical for tissue regeneration. Here, we develop a programmed therapeutic strategy based on arginine-lysine-methionine third-generation dendrimeric polypeptides whose dopamine-coated surfaces contain ferrous ions (G3D-Pmet

Indexed as

Cascade-released nanoplatformsCellular niche regulationDiabetic wound healingMacrophage plasticitySelf-assembling amphipathic peptides

Identifiers

PMID41492368
PMCPMC12765269

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.