Evidence map›Paper›PMID 41492160›Full record

ArticleJournal of neurogastroenterology and motility2026

Spatiotemporal Remodeling of Enteric Neural Pathways Underlies Colonic Dysmotility Following Spinal Cord Injury in Rats.

Min Seob Kim, Sei Kim, Se Eun Ha, Hyun Seok Choi, Myeong Hwan Yu, Jisong You, Dahyun Seon, Do Hee Lee, Min Cheol Joo, Yong Sung Kim and 6 more

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Article in Journal of neurogastroenterology and motility, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Min Seob KimDepartment of Physiology, School of Medicine, Wonkwang University, Digestive Disease Research Institute and Institute of Wonkwang Medical Science, Iksan, Jeonbuk-do, Korea.
Sei KimDepartment of Physiology, School of Medicine, Wonkwang University, Digestive Disease Research Institute and Institute of Wonkwang Medical Science, Iksan, Jeonbuk-do, Korea.
Se Eun HaDepartment of Physiology and Cell Biology, Reno School of Medicine, University of Nevada, Reno, NV, USA.
Hyun Seok ChoiDepartment of Physiology, School of Medicine, Wonkwang University, Digestive Disease Research Institute and Institute of Wonkwang Medical Science, Iksan, Jeonbuk-do, Korea.
Myeong Hwan YuDepartment of Physiology, School of Medicine, Wonkwang University, Digestive Disease Research Institute and Institute of Wonkwang Medical Science, Iksan, Jeonbuk-do, Korea.
Jisong YouDepartment of Physiology, School of Medicine, Wonkwang University, Digestive Disease Research Institute and Institute of Wonkwang Medical Science, Iksan, Jeonbuk-do, Korea.
Dahyun SeonDepartment of Physiology, School of Medicine, Wonkwang University, Digestive Disease Research Institute and Institute of Wonkwang Medical Science, Iksan, Jeonbuk-do, Korea.
Do Hee LeeDepartment of Rehabilitation Medicine, Wonkwang University, School of Medicine, Iksan, Jeonbuk-do, Korea.
Min Cheol JooDepartment of Rehabilitation Medicine, Wonkwang University, School of Medicine, Iksan, Jeonbuk-do, Korea.
Yong Sung KimDepartment of Gastroenterology, Digestive Disease Research Institute, Wonkwang University, School of Medicine, Iksan, Jeonbuk-do, Korea.
Suck Chei ChoiDepartment of Gastroenterology, Digestive Disease Research Institute, Wonkwang University, School of Medicine, Iksan, Jeonbuk-do, Korea.
Joong Goo KwonDepartment of Internal Medicine, Daegu Catholic University School of Medicine, Daegu, Korea.
Kyung Sik ParkDepartment of Gastroenterology, Keimyung University Daegu Dongsan Hospital, Daegu, Korea.
Hyun Jin KimDepartment of Gastroenterology, Gyeongsang National University, School of Medicine, Jinju-si, Gyeongsangnam-do, Korea.
Seungil RoDepartment of Physiology and Cell Biology, Reno School of Medicine, University of Nevada, Reno, NV, USA.
Moon Young LeeDepartment of Physiology, School of Medicine, Wonkwang University, Digestive Disease Research Institute and Institute of Wonkwang Medical Science, Iksan, Jeonbuk-do, Korea.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background/Aims: : Spinal cord injury (SCI) frequently impairs defecation, severely affecting the quality of life. This study examines compensatory neural remodeling after SCI, focusing on basal colonic contractility, neural responses to electrical field stimulation, and alterations in excitatory cholinergic and inhibitory nitrergic pathways. Methods: : Female Sprague-Dawley rats underwent either sham surgery or T10 spinal cord transection and were categorized into 3 groups: sham, 1-week post-SCI (acute), and 4-week post-SCI (chronic). Colonic contractility was assessed in an organ bath using electrical field stimulation in the presence of a nitric oxide synthase inhibitor. Neural protein expression was analyzed by immunofluorescence and Western blotting. Results: : SCI produced region- and time-dependent impairments in colonic contractility, with distinct alterations in the proximal circular and longitudinal muscles across acute and chronic phases. Neural excitability shifted dynamically, showing enhanced excitatory activity in the proximal longitudinal muscle at 1-week and the distal circular muscle at 4-week post-SCI. Protein analysis revealed increased neuronal nitric oxide synthase in the proximal colon, decreased soluble guanylyl cyclase in the distal colon, upregulated muscarinic M Conclusion: : SCI induces spatiotemporal remodeling of excitatory and inhibitory neural pathways, contributing to colonic dysmotility and revealing potential targets for therapeutic intervention.

Indexed as

ColonDefecationDysmotilityNeurogenic bowelSpinal cord injuries

Identifiers

PMID41492160
PMCPMC12780905

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.