Evidence map›Paper›PMID 41492127›Full record

SynthesisBMC pulmonary medicine2026

Sexually dimorphic response to tobacco exposure in COPD: a systematic review and meta-analysis.

Ryan Chow, Michelle Pham, Matthew Cope, Jean Wang, Ramtin Ghasemi, Sarah Yang, David Le Nguyen, Sami Aftab Abdul, Sanathan Sadh, Alexander Xiang and 4 more

Abstract readSystematic ReviewMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in BMC pulmonary medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Ryan ChowUniversity of Ottawa, Faculty of Medicine, Ottawa, Canada.
Michelle PhamUniversity of Western, Faculty of Medical Sciences, London, Canada.
Matthew CopeUniversity of Ottawa, Faculty of Medicine, Ottawa, Canada.
Jean WangThe Ottawa Hospital, Department of Medicine, 501 Smyth Rd, Ottawa, Ottawa, ON, K1H8L6, Canada.
Ramtin GhasemiUniversity of Ottawa, Faculty of Medicine, Ottawa, Canada.
Sarah YangUniversity of Ottawa, Faculty of Medicine, Ottawa, Canada.
David Le NguyenUniversity of Ottawa, Faculty of Medicine, Ottawa, Canada.
Sami Aftab AbdulUniversity of Ottawa, Faculty of Medicine, Ottawa, Canada.
Sanathan SadhQueens University, Faculty of Science, Kingston, Canada.
Alexander XiangMcMaster University, Faculty of Health Sciences, Hamilton, Canada.
Preshit AmbadeOttawa Hospital Research Institute, Ottawa, Canada.
Razan FrancesThe Ottawa Hospital, Department of Medicine, 501 Smyth Rd, Ottawa, Ottawa, ON, K1H8L6, Canada.
Risa ShorrOttawa Hospital Research Institute, Ottawa, Canada.
Smita PakhaleThe Ottawa Hospital, Department of Medicine, 501 Smyth Rd, Ottawa, Ottawa, ON, K1H8L6, Canada. spakhale@toh.ca.

Funding

Mitacs IT35932
6 · The paper itself

Abstract

backgroundChronic obstructive pulmonary disease (COPD) is a heterogeneous, progressive pulmonary disorder with persistent respiratory symptoms resulting from abnormalities in the airways and/or alveoli and was prevalent globally in 10.3% of people aged 30-79 years in 2019. The prevalence of COPD has increased rapidly in women in the past decade. This may be due to increased tobacco use, but may also involve sex-specific factors. PURPOSE: To evaluate the prevalence of COPD in the context of sex and tobacco exposure. DATA SOURCES AND SEARCHES: Comprehensive searches of MEDLINE (OVID), EMBASE and CENTRAL were conducted for articles published from inception to July 22, 2022. STUDY SELECTION: We independently evaluated titles, abstracts and full-text articles in a duplicated two-staged process. Studies were included if they reported the prevalence of COPD as a primary outcome in the context of sex and tobacco exposure. DATA SYNTHESIS AND ANALYSIS: Pooled analysis was conducted with Review Manager 5, and heterogeneity was assessed with the I LIMITATIONS: Included articles are limited by the quality of data on tobacco smoke exposure, primarily reported as a binary risk factor, with lack of availability on duration and intensity of exposure.

conclusionThere was earlier mortality and reduced FEV

Indexed as

Pulmonary Disease, Chronic ObstructiveAgedFemaleHumansMaleMiddle AgedPrevalenceSex Factors

Identifiers

PMID41492127
PMCPMC12870387

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.