Evidence map›Paper›PMID 41492113›Full record

ArticleAnnals of surgical oncology2026

Outcomes After Resection for Multiple Intrahepatic Cholangiocarcinoma-A National Population-Based Study.

Hannes Jansson, Helena Taflin, Bergthor Björnsson, Jozef Urdzik, Oskar Hemmingsson, Jenny Lundmark Rystedt, Stefan Gilg, Per Sandström, Ernesto Sparrelid

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In one paragraph

Article in Annals of surgical oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Hannes JanssonDivision of Surgery and Oncology, Department of Clinical Science, Intervention and Technology, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden. hannes.jansson@ki.se.ORCID http://orcid.org/0000-0002-1833-854X
Helena TaflinDepartment of Transplantation, Institute of Clinical Sciences, University of Gothenburg, Sahlgrenska Academy, Gothenburg, Sweden.
Bergthor BjörnssonDepartment of Biomedical and Clinical Sciences, Linköping University, Linköping, Sweden.
Jozef UrdzikDepartment of Surgical Sciences, Uppsala University, Uppsala, Sweden.
Oskar HemmingssonDepartment of Diagnostics and Intervention, Umeå University, Umeå, Sweden.
Jenny Lundmark RystedtDepartment of Surgery, Skåne University Hospital, Lund, Sweden.
Stefan GilgDivision of Surgery and Oncology, Department of Clinical Science, Intervention and Technology, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden.
Per SandströmDepartment of Biomedical and Clinical Sciences, Linköping University, Linköping, Sweden.
Ernesto SparrelidDivision of Surgery and Oncology, Department of Clinical Science, Intervention and Technology, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundTumor multiplicity is a negative prognostic factor in intrahepatic cholangiocarcinoma (iCCA) and the role of surgical resection in multiple iCCA remains unclear. PATIENTS AND

methodsData were extracted from the Swedish quality registry for cancers of the liver and biliary tract, for all patients undergoing surgery for iCCA (2010-2021). Validation was performed with all Swedish hepatobiliary referral centers, including a comparison cohort of patients with liver-only multiple iCCA and nonsurgical therapy. The primary endpoint was overall survival (OS).

resultsOut of 338 patients operated for iCCA, 284 had resectable tumors and 54 (16.0%) unresectable disease at exploration. In the resection and exploration groups, 46 (16.2%) and 11 patients (20.4%), respectively, had multiple lesions. A majority of patients with resection for multiple iCCA had two or three lesions (63.0%), with median OS 27.1 months (95% CI 18.8-35.5), compared with 5.3 months (95% CI 3.8-6.8) for patients with unresectable disease (P < 0.001). For patients with four or more lesions, OS with resection was similar as with unresectable disease (P = 0.922). In multiple iCCA, resection was associated with better performance status (P = 0.007), negative lymph nodes (P = 0.028), and smaller tumors (P = 0.004). With adjustment including these factors, resection was not significantly associated with OS (P = 0.090).

conclusionsResection for multiple iCCA with four or more lesions was not associated with a survival benefit compared with exploration. With selection to surgery for patients with good performance status, smaller tumors and no signs of lymph node metastasis, resection for two or three lesions yielded median OS above 2 years.

Indexed as

Bile Duct NeoplasmsCholangiocarcinomaHepatectomyNeoplasms, Multiple PrimaryAdultAgedAged, 80 and overFemaleFollow-Up StudiesHumansMaleMiddle AgedPrognosisRegistriesSurvival RateSwedenBiliary tract cancerIntrahepatic cholangiocarcinomaLiver resectionPrognosisResection

Identifiers

PMID41492113
PMCPMC12982245

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.