Evidence map›Paper›PMID 41492058›Full record

ArticleJournal of mass spectrometry : JMS2026

Lipidomic Comparison of Detergent-Soluble and Detergent-Resistant Lipid Domains Isolated From Rat Cerebellum and the Effect of Hypoxia-Ischemia Using UPLC-HDMS

Samuel A Krug, Min He, Ningfeng Tang, Cynthia Bearer, Maureen A Kane

Abstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of mass spectrometry : JMS, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Samuel A KrugDepartment of Pharmaceutical Sciences, University of Maryland School of Pharmacy, Baltimore, Maryland, USA.
Min HeDepartment of Pediatrics, University of Maryland School of Medicine, Baltimore, Maryland, USA.
Ningfeng TangDepartment of Pediatrics, University of Maryland School of Medicine, Baltimore, Maryland, USA.
Cynthia BearerDepartment of Pediatrics, University of Maryland School of Medicine, Baltimore, Maryland, USA.ORCID https://orcid.org/0000-0003-4809-2250
Maureen A KaneDepartment of Pharmaceutical Sciences, University of Maryland School of Pharmacy, Baltimore, Maryland, USA.ORCID https://orcid.org/0000-0002-5525-9170

Funding

Project IV- Cerebellar Function After Hypoxia-Ischemia and Precipitating InflammationP01HD085928 · NICHD · UNIVERSITY OF MARYLAND BALTIMORE · PI BEARER, CYNTHIA FRANCES · 2016 to 2020
$6.3M
NICHD NIH HHS P01 HD085928
6 · The paper itself

Abstract

Hypoxic ischemic encephalopathy (HIE) due to insufficient oxygen or blood flow to the brain can result in inflammation, impaired neurodevelopment, or death. Changes to microdomain lipid composition may contribute to altered structure and function of key regulatory processes; however, knowledge regarding changes to membrane lipid composition after HIE is incomplete. Here, we describe the application of untargeted lipidomics to investigate the impact of hypoxia-ischemia on detergent-resistant membrane (DRM) and detergent-soluble membrane (DSM) domains fractionated from the cerebellum in a rat model of HIE. Lipidomics utilized ultra performance liquid chromatography coupled to data independent tandem mass spectrometry with traveling wave ion mobility. Lipid alterations specific to the DRM domains after hypoxia-ischemia included lysophospholipids, sphingomyelins, ceramides, triglycerides, and phosphatidylethanolamines, which are lipid species that have been linked to cognitive and neuronal impairment. The advances in lipidomics have enabled the tools available to study lipid composition. These data may provide insight into membrane disruption after HIE in relation to lipid composition and concentration.

Indexed as

CerebellumHypoxia-Ischemia, BrainLipidomicsLipidsMembrane MicrodomainsAnimalsChromatography, High Pressure LiquidDetergentsMaleRatsRats, Sprague-DawleyTandem Mass SpectrometryDetergentsLipidshypoxic ischemialipid membranelipidomicsliquid chromatography–tandem mass spectrometrymembrane domains

Identifiers

PMID41492058
PMCPMC12770806

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.