Evidence map›Paper›PMID 41491859›Full record

ArticleOdontology2026

Bleaching efficacy and reduction of cytotoxicity of 6% H₂O₂ in-office bleaching gels formulated with hyaluronic acid, NF_TiO₂ nanoparticles, and violet LED irradiation: in vitro study.

Priscila Borges Gobbo de Melo, Marcos Roberto de Lima Benati, Matheus Kury, Rafael Antônio de Oliveira Ribeiro, Carlos Alberto de Souza Costa, Fernando Luis Esteban Florez, Vanessa Cavalli

Abstract read
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In one paragraph

Article in Odontology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Priscila Borges Gobbo de MeloDepartment of Restorative Dentistry, Piracicaba Dental School, University of Campinas, Avenida Limeira, 901, Piracicaba, SP, Brazil.
Marcos Roberto de Lima BenatiDepartment of Restorative Dentistry, Piracicaba Dental School, University of Campinas, Avenida Limeira, 901, Piracicaba, SP, Brazil.
Matheus KuryDental Research Division, School of Dentistry, Paulista University (UNIP), São Paulo, SP, Brazil.
Rafael Antônio de Oliveira RibeiroDepartment of Dental Materials and Prosthodontics, School of Dentistry, São Paulo State University (UNESP), Araraquara, SP, Brazil.
Carlos Alberto de Souza CostaDepartment of Physiology and Pathology, School of Dentistry, São Paulo State University (UNESP), Araraquara, SP, Brazil.
Fernando Luis Esteban FlorezDepartment of Restorative Sciences, University of Oklahoma - Health Sciences Center, Oklahoma City, OK, USA.
Vanessa CavalliDepartment of Restorative Dentistry, Piracicaba Dental School, University of Campinas, Avenida Limeira, 901, Piracicaba, SP, Brazil. cavalli@unicamp.br.ORCID http://orcid.org/0000-0002-9459-1926

Funding

CAPES 001FAPESP 2021/14834-7
6 · The paper itself

Abstract

The objective is to evaluate the bleaching efficacy and cytotoxicity of innovative low-concentration in-office gels containing 6% hydrogen peroxide (H₂O₂), hyaluronic acid (HA), or carbomer 940 (CAR) as thickeners, titanium dioxide nanoparticles co-doped with nitrogen and fluorine (NF_TiO₂) and irradiated with violet LED. Bovine enamel/dentin disks adapted to artificial pulp chambers were randomly assigned to seven groups (n = 8): NC (negative control), HP35 (commercial control), HA, HA-HP6 + LED, HA-HP6-NP + LED, CAR-HP6 + LED, and CAR-HP6-NP + LED. The bleaching protocol consisted of three 30-min sessions conducted at 7-day intervals, each session involving 20 violet LED cycles (1-min activation / 30-s pause). Bleaching efficacy was assessed by measuring color change (ΔE₀₀) and whiteness index (ΔWI

Indexed as

Hyaluronic AcidHydrogen PeroxideNanoparticlesTitaniumTooth BleachingTooth Bleaching AgentsAnimalsCattleCell SurvivalGelsIn Vitro TechniquesGelsHyaluronic AcidHydrogen PeroxideTitaniumtitanium dioxideTooth Bleaching AgentsHyaluronic acidHydrogen peroxideTitaniumTooth bleachingViolet LED

Identifiers

PMID41491859
PMCPMC13631033

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.