ArticleCommunications medicine2026
Dose-related association between radiation exposure from computed tomography (CT) scans during trauma hospitalizations and subsequent risk of developing new-onset cancers.
Article in Communications medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundThe association between radiation dose from Computed Tomography (CT) and subsequent cancer risk in adults remains poorly defined.
methodsWe conducted a statewide cohort study to examine the relationship between CT-related radiation exposure - measured by dose-length-product (DLP) - and cancer outcomes among adult trauma patients in Western Australia from 2004 to 2020. Patients with a documented cancer diagnosis within five years prior to trauma were excluded.
resultsAfter excluding patients with missing smoking data (n = 12,690), 2662 patients (17.3%) are included in the primary analysis. The cohort is predominantly male (75.8%), with a median age of 41 years (IQR: 27-58) and a median Injury Severity Score (ISS) of 17 (IQR: 16-22). Over a median follow-up of 5.9 years (IQR: 4.0-7.9), 374 patients (14.0%) died, including 21 cancer-related deaths (0.8%), accounting for 5.6% of all deaths. During the index trauma admission, patients underwent a median of 6 X-rays (IQR: 3-12) and 3 CT scans (IQR:1-5) with a median DLP of 1,941 mGy*cm (IQR: 637-3,388). DLP and absorbed radiation dose are significantly correlated with injury severity (Pearson r = 0.209 and 0.265, respectively; both p = 0.001). Radiation exposure is significantly associated with increased risk of new-onset cancer (adjusted hazard ratio [aHR]: 1.08 per 1,000 mGy*cm increment in DLP; 95%CI: 1.01-1.16; p = 0.042) and cancer-related mortality (aHR 3.35 for those exposed to >5000 mGy*cm; 95%CI: 1.20-9.38; p = 0.021). These findings are consistent in a larger cohort of 15,352 patients after multiple imputation for missing smoking data.
conclusionsCT-related radiation exposure during trauma hospitalizations is associated with a dose-dependent increase in the risk of subsequent cancer incidence and mortality.
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