Evidence map›Paper›PMID 41491842›Full record

ArticleMolecular psychiatry2026

RO4938581, a GABA

Ryoko Nakagawa, Francesca Nani, Joerg F Hipp, Michael Honer, Frederic Knoflach, Rodolfo Gasser, Laurence Ozmen, Kota Tamada, Fatiha Fjeldskaar, Livia Takacs and 5 more

Abstract read
In one paragraph

Article in Molecular psychiatry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Functionalized Biomimetic Scaffolds for Human-Derived Auditory Neural Circuit Construction.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
  2. The role of GABANeuroscience and biobehavioral reviews · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Ryoko Nakagawa *Pharma Research and Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd., Basel, 4070, Switzerland.
Francesca Nani *Pharma Research and Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd., Basel, 4070, Switzerland.ORCID http://orcid.org/0009-0002-5955-7244
Joerg F HippPharma Research and Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd., Basel, 4070, Switzerland.ORCID http://orcid.org/0000-0002-7875-2988
Michael HonerPharma Research and Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd., Basel, 4070, Switzerland.ORCID http://orcid.org/0000-0003-4818-9984
Frederic KnoflachPharma Research and Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd., Basel, 4070, Switzerland.
Rodolfo GasserPharma Research and Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd., Basel, 4070, Switzerland.
Laurence OzmenPharma Research and Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd., Basel, 4070, Switzerland.
Kota TamadaRIKEN Brain Science Institute, Wako, Saitama, 351-0198, Japan.
Fatiha FjeldskaarPharma Research and Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd., Basel, 4070, Switzerland.
Livia TakacsPharma Research and Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd., Basel, 4070, Switzerland.
Audrey VauthenyPharma Research and Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd., Basel, 4070, Switzerland.
Stephen R MorairtySRI Biosciences, Center for Neuroscience, Menlo Park, CA, 94025, USA.ORCID http://orcid.org/0000-0002-0781-1645
Michael SaxePharma Research and Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd., Basel, 4070, Switzerland.
Toru TakumiRIKEN Brain Science Institute, Wako, Saitama, 351-0198, Japan.ORCID http://orcid.org/0000-0001-7153-266X
Maria-Clemencia HernandezPharma Research and Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd., Basel, 4070, Switzerland. maria-clemencia.hernandez@roche.com.ORCID http://orcid.org/0000-0003-1621-4188

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We investigated the correlation between increased gene copy number of gamma aminobutyric acid type A (GABA

Indexed as

Chromosome DisordersReceptors, GABA-AAllosteric RegulationAnimalsBehavior, AnimalBrainChromosome AberrationsChromosomes, Human, Pair 15Disease Models, AnimalElectroencephalographyFemaleHippocampusHumansIntellectual DisabilityMaleMiceGabra5 protein, mouseReceptors, GABA-A

Identifiers

PMID41491842
PMCPMC12916284

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.