Evidence map›Paper›PMID 41491834›Full record

ArticleEuropean journal of medical research2026

Elevated IL-8 and abnormal lymphocytes in pediatric primary Sjögren's syndrome: a single-center study.

Xian Fei Gao, Wen Tang, Xiaoyou Huang, Yifan Liua, Jiawei Zhou, Zhirui Nie, Mingqi Zhao, Ying Tang, Feng Li, Caihong Xu and 2 more

Abstract read
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In one paragraph

Article in European journal of medical research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

12 authors.

Xian Fei GaoDepartment of Pediatrics, Allergy, Immune and Rheumatology, Guangzhou Women and Children's Medical Center, Guangdong Provincial Clinical Research Center for Child Health, Guangdong Province Key Laboratory of Allergy & Clinical Immunology, Guangzhou Medical University, Guangzhou, 510623, China.
Wen Tang *School of Stomatology, Southern Medical University, Guangzhou, 510091, China.
Xiaoyou HuangSchool of Stomatology, Southern Medical University, Guangzhou, 510091, China.
Yifan Liua
Jiawei ZhouDepartment of Oral and Maxillofacial Surgery, Guangzhou Women and Children's Medical Center, Guangdong Provincial Clinical Research Center for Child Health, Guangzhou Medical University, Guangzhou, 510623, China.
Zhirui NieDepartment of Pediatric Orthopedics, GuangZhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, 510623, China.
Mingqi ZhaoCenter Laboratory, Guangzhou Women and Children's Medical Center, Guangzhou Medical University, Guangzhou, 510623, China.
Ying TangDepartment of Pediatrics, Allergy, Immune and Rheumatology, Guangzhou Women and Children's Medical Center, Guangdong Provincial Clinical Research Center for Child Health, Guangdong Province Key Laboratory of Allergy & Clinical Immunology, Guangzhou Medical University, Guangzhou, 510623, China.
Feng LiDepartment of Pediatrics, Allergy, Immune and Rheumatology, Guangzhou Women and Children's Medical Center, Guangdong Provincial Clinical Research Center for Child Health, Guangdong Province Key Laboratory of Allergy & Clinical Immunology, Guangzhou Medical University, Guangzhou, 510623, China.
Caihong XuDepartment of Pediatrics, Allergy, Immune and Rheumatology, Guangzhou Women and Children's Medical Center, Guangdong Provincial Clinical Research Center for Child Health, Guangdong Province Key Laboratory of Allergy & Clinical Immunology, Guangzhou Medical University, Guangzhou, 510623, China.
Huishan ChenDepartment of Pediatrics, Allergy, Immune and Rheumatology, Guangzhou Women and Children's Medical Center, Guangdong Provincial Clinical Research Center for Child Health, Guangdong Province Key Laboratory of Allergy & Clinical Immunology, Guangzhou Medical University, Guangzhou, 510623, China.
Ping ZengDepartment of Pediatrics, Allergy, Immune and Rheumatology, Guangzhou Women and Children's Medical Center, Guangdong Provincial Clinical Research Center for Child Health, Guangdong Province Key Laboratory of Allergy & Clinical Immunology, Guangzhou Medical University, Guangzhou, 510623, China. zengpingtom@126.com.

Funding

GuangDong Basic and Applied Basic Research Foundation 2025A1515012735Guangzhou Women and Children's Medical Center 1600218Municipal and University (Hospital) Joint Funding Project of Guangzhou Municipal Science and Technology Bureau 2023A03J0902
6 · The paper itself

Abstract

Cytokines and lymphocytes orchestrating the pathophysiological landscape have been well explored in adults but remains understudied in children. This study evaluated their potential as biomarkers in diagnosis of pediatric Sjögren's syndrome (pSS). We retrospectively analyzed 14 pediatric patients with pSS who attended our rheumatology clinic over 2 years. Plasma levels of IL-4, IL-5, TNF-α, IFN-γ, TNF-β, IL-6, IL-1β, IL-2, IL-10, IL-8, IL-22, IL-12p70, IL-17F, and IL-17A, as well as percentages and absolute counts of CD3 + , CD19 + , CD3-CD16 + /CD56 + , CD3 + CD4 + , and CD3 + CD8 + lymphocytes, were measured in 14 pSS patients and 12 healthy controls. IL-8 levels were elevated in pSS patients compared to controls. CD3 + CD8 + lymphocytes were increased, while CD3 + , CD3 + CD4 + , CD19 + , and CD3-CD16 + /CD56 + lymphocytes were decreased in pSS patients. IL-8 may be a potential indicator for the early diagnosis of pSS, together with T-, B-, and NK-cell abnormalities, may contribute to disease pathogenesis. Larger studies are needed to confirm these findings.

Indexed as

Interleukin-8LymphocytesSjogren's SyndromeAdolescentBiomarkersCase-Control StudiesChildFemaleHumansMaleRetrospective StudiesBiomarkersCXCL8 protein, humanInterleukin-8

Identifiers

PMID41491834
PMCPMC12870891

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.