Evidence map›Paper›PMID 41491823›Full record

ArticleBMC veterinary research2026

Dual deletion of ugd and phoB Attenuates virulence and enhances vaccine potential in Aeromonas dhakensis.

Xuesong Li, Mengqi Wang, Liqing Chen, Haibo Gao, Yanrong Lin, Yukun Wu, Shuai Ye, Aodi Yi, Guiying Guo, Lixia Fan and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC veterinary research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Xuesong Li *Lab of Microbiological Engineering (Infection and Immunity), School of Life and Health Sciences, Hainan Province Key Laboratory of One Health, Collaborative Innovation Center of One Health, Hainan University, Haikou, Hainan, 570228, China.
Mengqi Wang *Lab of Microbiological Engineering (Infection and Immunity), School of Life and Health Sciences, Hainan Province Key Laboratory of One Health, Collaborative Innovation Center of One Health, Hainan University, Haikou, Hainan, 570228, China.
Liqing ChenLab of Microbiological Engineering (Infection and Immunity), School of Life and Health Sciences, Hainan Province Key Laboratory of One Health, Collaborative Innovation Center of One Health, Hainan University, Haikou, Hainan, 570228, China.
Haibo GaoDongfang Hewangxin Breeding Co., Ltd, Dongfang, 572600, China.
Yanrong LinLab of Microbiological Engineering (Infection and Immunity), School of Life and Health Sciences, Hainan Province Key Laboratory of One Health, Collaborative Innovation Center of One Health, Hainan University, Haikou, Hainan, 570228, China.
Yukun WuLab of Microbiological Engineering (Infection and Immunity), School of Life and Health Sciences, Hainan Province Key Laboratory of One Health, Collaborative Innovation Center of One Health, Hainan University, Haikou, Hainan, 570228, China.
Shuai YeLab of Microbiological Engineering (Infection and Immunity), School of Life and Health Sciences, Hainan Province Key Laboratory of One Health, Collaborative Innovation Center of One Health, Hainan University, Haikou, Hainan, 570228, China.
Aodi Yi *Lab of Microbiological Engineering (Infection and Immunity), School of Life and Health Sciences, Hainan Province Key Laboratory of One Health, Collaborative Innovation Center of One Health, Hainan University, Haikou, Hainan, 570228, China.
Guiying GuoSchool of Chemical Engineering and Technology, Hainan University, Haikou, 570228, China.
Lixia FanLab of Microbiological Engineering (Infection and Immunity), School of Life and Health Sciences, Hainan Province Key Laboratory of One Health, Collaborative Innovation Center of One Health, Hainan University, Haikou, Hainan, 570228, China.
Nuo YangLab of Microbiological Engineering (Infection and Immunity), School of Life and Health Sciences, Hainan Province Key Laboratory of One Health, Collaborative Innovation Center of One Health, Hainan University, Haikou, Hainan, 570228, China.
Jifeng ZengLab of Microbiological Engineering (Infection and Immunity), School of Life and Health Sciences, Hainan Province Key Laboratory of One Health, Collaborative Innovation Center of One Health, Hainan University, Haikou, Hainan, 570228, China.
Jiping ZhengLab of Microbiological Engineering (Infection and Immunity), School of Life and Health Sciences, Hainan Province Key Laboratory of One Health, Collaborative Innovation Center of One Health, Hainan University, Haikou, Hainan, 570228, China. jiping.zheng@hainanu.edu.cn.

Funding

Hainan Dongfang National Modern Agricultural Industrial Park Project 3.2the Hainan University High-level Talent Scientific Research Start-up Fund RZ2300002761the Innovative Research Projects for Postgraduates in Hainan Province Qhys2023-186the Innovative Research Projects for Postgraduates in Hainan Province Qhys2024-51the Key Research and Development Program of Hainan Province ZDYF2024SHFZ142the Key Research and Development Program of Hainan Province ZDYF2024XDNY198the National Natural Science Foundation of China 32360879
6 · The paper itself

Abstract

Aeromonas dhakensis, an increasingly prevalent pathogen in tropical areas, presents significant risks to public health and the aquaculture industry. This research evaluates the virulence effects of ugd and phoB gene deletions. The double gene deletion mutant strain ΔugdΔphoB was obtained by further knocking out the ugd gene in the previously constructed single mutant strain ΔphoB. Phenotypic analyses under phosphate-deficient conditions showed marked decreases in both growth and motility for the Δugd and ΔugdΔphoB mutants compared to the wild type. Conversely, under phosphate-rich conditions, growth remained stable, although motility variations were noted. The mutants ΔugdΔphoB and Δugd exhibited diminished resistance to H

Indexed as

AeromonasBacterial ProteinsBacterial VaccinesFish DiseasesGram-Negative Bacterial InfectionsAnimalsBiofilmsGene DeletionVaccines, AttenuatedVirulenceBacterial ProteinsBacterial VaccinesVaccines, AttenuatedAeromonas dhakensisDouble mutant strainUgd and phoB genesVaccine candidatesVirulence

Identifiers

PMID41491823
PMCPMC12771805

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.