ReviewNature reviews. Genetics2026
Ancestral diversity in complex disease genetics: from discovery to translation.
Review in Nature reviews. Genetics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The expansion of ancestrally diverse genetic cohorts has altered the landscape of complex disease genetics. Differences in linkage disequilibrium across populations have improved fine-mapping and the identification of target genes - key steps for translating findings from genome-wide association studies into biological understanding. Whilst there is widespread sharing of genetic architecture across ancestries, loci that display heterogeneity in causal genetic effects across populations can offer unique biological insights. Here, we review how ancestral and global diversity shape genetic discoveries. As we advance towards global precision medicine, integrating genomic data with diverse environmental and social factors will be crucial to account for population-specific contexts that can influence disease risk or treatment response.
Indexed as
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41491820What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.