Evidence map›Paper›PMID 41491722›Full record

ArticleSupportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer2026

Meeting physical activity guidelines in conjunction with higher protein intake: associations with appendicular lean soft tissue index in middle aged adults with cancer.

Konstantinos Prokopidis, Stefano Cacciatore, Nicola Veronese, Brendon Stubbs, Paolo Piaggi, John A Batsis, Carla M Prado, Mathias Schlögl

Abstract read
In one paragraph

Article in Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Konstantinos ProkopidisDepartment of Musculoskeletal and Ageing Science, Institute of Life Course and Medical Sciences, University of Liverpool, Liverpool, L7 8TX, UK. k.prokopidis@liverpool.ac.uk.ORCID http://orcid.org/0000-0002-6264-9388
Stefano CacciatoreDepartment of Geriatrics, Orthopedics and Rheumatology, Università Cattolica del Sacro Cuore, L.Go F. Vito 1, 00168, Rome, Italy.
Nicola VeroneseGeriatric Unit, Department of Medicine, University of Palermo, Palermo, Italy.
Brendon StubbsDepartment of Psychological Medicine, Institute of Psychiatry, Psychology and Neuroscience (IoPPN), King's College London, London, UK.
Paolo PiaggiDepartment of Information Engineering, University of Pisa, Pisa, Italy.
John A BatsisDepartment of Nutrition, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Carla M PradoDepartment of Agricultural, Food & Nutritional Science, University of Alberta, Edmonton, Canada.
Mathias SchlöglClinic Barmelweid, Department for Geriatric Medicine, Erlinsbach, Switzerland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundLoss of muscle mass is a common concern among patients with cancer. The aim of this study was to examine whether meeting the World Health Organization physical activity guidelines in combination with a higher vs. lower than the recommended daily allowance (RDA) protein intake is associated with greater appendicular lean soft tissue index (ALSTI) in adults aged 40-59 years with cancer from the National Health and Nutrition Examination Survey.

methodsParticipants were categorized by physical activity levels (moderate ≥ 150 min/week or vigorous ≥ 75 min/week) and protein intake (> 0.8 vs. ≤ 0.8 g/kg/day) assessed via two interviewer-administered 24-h dietary recalls. ALSTI was calculated using dual-energy X-ray absorptiometry (kg/m

resultsAmong 169 participants (mean age 51.0 ± 5.6 years; 69% women, mean ALSTI 7.74 ± 1.66 kg/m

conclusionsMeeting vigorous or moderate physical activity guidelines in combination with higher vs. lower protein intake was not associated with ALSTI in adults with cancer. However, meeting both was positively linked to ALSTI. Longitudinal and interventional studies using objective measures and longitudinal designs are needed to clarify the role of physical activity with adequate protein intake in preserving muscle health in this clinical population.

Indexed as

Dietary ProteinsExerciseNeoplasmsAbsorptiometry, PhotonAdultBody CompositionCross-Sectional StudiesFemaleHumansLinear ModelsMaleMiddle AgedNutrition SurveysRecommended Dietary AllowancesSarcopeniaDietary ProteinsCancerMuscle wastingNutritionProtein intakeSarcopenia

Identifiers

PMID41491722
PMCPMC12769968

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.