Observational studyBMC pediatrics2026
Prenatal-postnatal integrated management model improves outcomes of neonatal cardiac surgery in critical congenital heart disease: a retrospective cohort study.
Observational study in BMC pediatrics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06768008 (Clinical Study of an Integrated Prenatal and Postnatal Treatment Model to Improve the Treatment Effect of Newborns With Critical Congenital Heart Disease), which is not on this map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Clinical Study of an Integrated Prenatal and Postnatal Treatment Model to Improve the Treatment Effect of Newborns With Critical Congenital Heart Disease
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
backgroundNeonates with CCHD remain at high risk for mortality. This study aimed to evaluate the impact of the prenatal-postnatal integrated management model (PPIMM) on perioperative outcomes and mortality in neonates with CCHD, and to identify factors associated with mortality.
methodsThis retrospective cohort study enrolled 274 neonates with CCHD undergoing cardiac surgery from January 2018 to August 2024. Patients were categorized into the PPIMM group (n = 140) and the non-PPIMM group (n = 134). The primary outcome was all-cause mortality, including operative mortality and late mortality. The secondary outcome was unplanned reoperation. Kaplan-Meier survival and Cox regression analyses were performed.
resultsThe PPIMM group underwent surgery at a younger age (8.00 vs. 16.00 days, P < 0.001), with lower rates of preoperative intubation (11.43% vs. 20.90%, P = 0.047), emergent procedures (5.71% vs. 14.18%, P = 0.032), and operative mortality (5.71% vs. 13.43%, P = 0.036) compared to the non-PPIMM group. The median follow-up was 20.70 months (IQR 9.00-30.30) in the PPIMM group and 20.40 months (IQR 7.00-37.50) in the non-PPIMM group. Late mortality (3.57% vs. 4.48%, P = 0.702) and unplanned reoperation rates (P>0.05) were comparable between the PPIMM and non-PPIMM groups. Kaplan-Meier analysis showed a significant survival advantage for all-cause mortality in the PPIMM group (log-rank P = 0.038). Twelve neonates underwent immediate postnatal surgery, with no deaths or reoperations during a median follow-up of 13.00 months. PPIMM was a protective factor for operative mortality in the overall cohort, and prenatal diagnosis was protective within the non-PPIMM subgroup, while preoperative intubation, postoperative ECMO use, and elevated lactate level at 24 h postoperatively were risk factors.
conclusionsPPIMM was associated with earlier surgery, better preoperative status, and lower operative mortality in neonates with CCHD. In selected neonates, immediate postnatal surgery appeared feasible and was not associated with increased mortality. PPIMM and prenatal diagnosis were protective factors, whereas preoperative intubation, postoperative ECMO, and elevated lactate at 24 h postoperatively were risk factors for operative mortality.
trial registrationRetrospectively registered at ClinicalTrials.gov (NCT06768008), 2025-01-03.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.