ReviewBMC women's health2026
Advanced primary fallopian tube cancer was found during chemotherapy for multiple myeloma: a case report and literature.
Review in BMC women's health, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundMultiple myeloma (MM) is a common malignant tumor of the blood system, on the other hand, the incidence of fallopian tube cancer is low, accounting for only 0.1%~1.8% of gynecological malignant tumors. It is extremely rare for these two diseases to occur together. In this paper, we present a case of primary fallopian tube cancer that was discovered and metastasized to the ovary during chemotherapy for MM, and we review the literature. CASE PRESENTATION: The patient was 69 years old and had been postmenopausal for 19 years. She was admitted to the hospital due to abnormal vaginal discharge lasting for one week. She had a history of MM for 5 years and had just completed 13 courses of treatment with daretuzumab. Doppler ultrasound and pelvic computed tomography(CT) revealed tubal and ovarian lesions with a high probability of malignancy. Laparoscopic exploration was performed, and frozen pathology confirmed the presence of malignant tumors originating from the right adnexa. The bilateral fallopian tubes and ovaries were removed. Postoperative paraffin pathology showed right fallopian tube cancer with ovarian metastasis. Following the surgery, the patient received three sessions of hyperthermic intraperitoneal therapy and one session of carboplatin and paclitaxel chemotherapy. Currently, the patient is in a generally stable condition and is awaiting the second round of chemotherapy.
conclusionThe coexistence of MM and primary fallopian tube carcinoma is an extremely rare occurrence. When a pelvic mass is detected in patients with multiple myeloma, it is important to consider the possibility of a second primary tumor in addition to myeloma metastasis. Managing patients with this dual malignancy presents a significant challenge for clinicians. Treatment plans should be developed through multidisciplinary collaboration, taking into account the severity of the disease and the patient's physical condition. Close monitoring is necessary during the perioperative period, as these patients are susceptible to infection and kidney damage. It is advisable for patients and their children to undergo genetic testing in order to implement appropriate preventive measures.
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