Trial reportScientific reports2026
Analysis of correlation between structural changes and functional response in post-stroke motor recovery after cM1 LF-rTMS: an exploratory randomized trial.
Trial report in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
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Corrections and comments
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The relationship between motor recovery and changes in brain structural and functional connectivity after stroke remains unclear. This study quantified the correlation between post-stroke white matter changes and functional responses and explored the brain network mechanism of contralesional primary motor cortex (cM1) low-frequency repetitive transcranial magnetic stimulation (LF-rTMS) affecting the motor recovery after stroke. Fifty patients accepted cM1 LF-rTMS or sham stimulation. The changes in structural-functional (SC-FC) coupling at the whole-brain, hemispheric, and modular levels were evaluated. Hemispheric SC-FC coupling lateralization index (LI), intramodular and intermodular connectivity, and node participant coefficient (PC) were further analyzed. The motor function score of the rTMS group improved more significantly, which was positively correlated with the whole brain and the affected-side somatosensory/motor and auditory network SC-FC coupling, the hemispheric SC-FC coupling LI, the intermodular connectivity between the intact-side default mode network and the affected-side limbic/paralimbic and subcortical network, but negatively correlated with the SC-FC coupling in the intact-side hemisphere and somatosensory/motor and auditory network. cM1 LF-rTMS can regulate structural changes and functional responses of the whole-brain, hemispheric, and modular levels after stroke, and effectively promote the improvement of upper limb motor function. SC-FC coupling may be a sensitive biomarker for predicting post-stroke motor recovery.
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