Evidence map›Paper›PMID 41491293›Full record

SynthesisImmunogenetics2026

NKG2D genetic variants and cancer susceptibility: Integrating case-control evidence with meta-analysis.

Nguyen Hoang Viet, Le Thanh Dong, Do Tung Dac, Hai Ha Long Le, Le Thi Phuong, Pham Phuong Thao, Hoang Thao Giang Nguyen, J Luis Espinoza

Abstract readMeta-AnalysisSystematic Review
PubMed Publisher
In one paragraph

Synthesis in Immunogenetics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Nguyen Hoang Viet *Faculty of Medical Technology, Hanoi Medical University, Hanoi, Vietnam.
Le Thanh Dong *Department of Pathology, Faculty of Medicine, Kanazawa University, Kanazawa, Japan.
Do Tung DacFaculty of Health Sciences, Kanazawa University, Kanazawa, Ishikawa, Japan.
Hai Ha Long LeFaculty of Medical Technology, Hanoi Medical University, Hanoi, Vietnam.
Le Thi PhuongCenter for Gene and Protein Research, Hanoi Medical University, Hanoi, Vietnam.
Pham Phuong ThaoDepartment of Hematology, Hanoi Medical University, Hanoi, Vietnam.
Hoang Thao Giang NguyenFaculty of Health Sciences, Kanazawa University, Kanazawa, Ishikawa, Japan.
J Luis EspinozaFaculty of Health Sciences, Kanazawa University, Kanazawa, Ishikawa, Japan. luis@staff.kanazawa-u.ac.jp.

Funding

Grant-in-Aid for Scientific Research from JSPS KAKENHI 23K07830-00
6 · The paper itself

Abstract

Lymphomas are biologically heterogeneous malignancies with multifactorial etiologies involving genetic, environmental, and immune dysregulation. The functional variant rs1049174 SNP in the KLRK1 gene (encoding NKG2D) regulates NKG2D expression and modulates NK cells immune surveillance pathways, which may influence lymphoma susceptibility. We investigated this association through a two-stage case-control study and meta-analysis. First, we analyzed 246 diffuse large B-cell lymphoma (DLBCL) patients and 599 healthy controls (exploratory cohort), followed by a confirmatory cohort of 234 non-Hodgkin lymphoma (NHL)/Hodgkin lymphoma (HL) patients. Genotype frequencies were assessed via chi-square tests, with odds ratios (ORs) calculated for risk associations. A systematic review and meta-analysis of 10 studies, including our cohorts (3,785 cases and 4,129 controls), testing rs1049174 and cancer risk was also conducted. In the exploratory cohort, the GG genotype showed no significant association with overall lymphoma risk (OR = 0.83; 95% CI: 0.61-1.13; *p* = 0.25). However, in NHL, the GG genotype was underrepresented (OR = 0.75; 95% CI: 0.57-0.99; *p* = 0.02). Pooled lymphoma analysis revealed a protective effect (OR = 0.78; 95% CI: 0.62-0.99; *p* = 0.03). Meta-analysis confirmed a significant protective role of the GG genotype against cancer (OR = 0.71; 95% CI: 0.63-0.79), despite heterogeneity and potential publication bias. Our findings suggest that the rs1049174 GG genotype is associated with reduced lymphoma susceptibility, particularly in NHL, underscoring the importance of immunogenetic variants in lymphomagenesis. Further functional and clinical studies are needed to elucidate the mechanistic basis of this association.

Indexed as

Genetic Predisposition to DiseaseHodgkin DiseaseLymphoma, Large B-Cell, DiffuseNK Cell Lectin-Like Receptor Subfamily KPolymorphism, Single NucleotideCase-Control StudiesFemaleGene FrequencyGenotypeHumansLymphoma, Non-HodgkinMaleMiddle AgedOdds RatioKLRK1 protein, humanNK Cell Lectin-Like Receptor Subfamily KCancer immunogeneticsLymphoma susceptibilityNatural killer cell immunityNKG2D genetic polymorphismRs1049174

Identifiers

PMID41491293

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.