Evidence map›Paper›PMID 41491280›Full record

ArticleClinical epigenetics2026

Association between cardiovascular health and epigenetic aging: a twin study.

Hui Cao, Ziyun Jiang, Weihua Cao, Jun Lv, Canqing Yu, Tao Huang, Dianjianyi Sun, Chunxiao Liao, Yuanjie Pang, Runhua Hu and 7 more

Abstract readTwin Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Clinical epigenetics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

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0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Hui CaoDepartment of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing, China.
Ziyun JiangDepartment of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing, China.
Weihua CaoDepartment of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing, China.
Jun LvDepartment of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing, China.
Canqing YuDepartment of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing, China.
Tao HuangDepartment of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing, China.
Dianjianyi SunDepartment of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing, China.
Chunxiao LiaoDepartment of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing, China.
Yuanjie PangDepartment of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing, China.
Runhua HuDepartment of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing, China.
Ruqin GaoQingdao Center for Disease Control and Prevention, Qingdao, China.
Min YuZhejiang Center for Disease Control and Prevention, Hangzhou, China.
Jinyi ZhouJiangsu Center for Disease Control and Prevention, Nanjing, China.
Xianping WuSichuan Center for Disease Control and Prevention, Chengdu, China.
Yu LiuHeilongjiang Center for Disease Control and Prevention, Harbin, China.
Wenjing GaoDepartment of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing, China. pkuepigwj@126.com.
Liming LiDepartment of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing, China. lmleeph@vip.163.com.

Funding

the Beijing Natural Science Foundation 7244455the National Key Research and Development Program of China 2023YFC2705900the National Natural Science Foundation of China 82373659, 82073633, and 81573223the Special Fund for Health Scientific Research in the Public Welfare 201502006 and 201002007
6 · The paper itself

Abstract

objectiveTo explore the association between life's essential 8 and epigenetic age based on twins population.

methodsThis study included 1030 twins (515 pairs) for cross-sectional analysis and conducted cross-lagged analysis among 294 twins (147 pairs) who participated in both the baseline and follow-up surveys from the Chinese National Twin Registry. LE8 scores were obtained from measurements based on American Heart Association definitions. DNA methylation data were used to calculate epigenetic age metrics, including GrimAA, DamAA and DunedinPACE. Linear mixed-effect models were applied for cross-twin analyses and within-monozygotic-pair analyses.

resultsIn the cross-sectional analysis, higher LE8 score was associated with slower epigenetic aging (DunedinPACE and DamAA) in both across-twin analyses and within-monozygotic-pair analyses. In stratified analyses, the association between LE8 score and epigenetic age appeared more significant in males and in individuals aged 50 years older. The cross-lagged analysis further revealed significant temporal associations between LE8, health factor, and DunedinPACE.

conclusionHigher LE8 scores were associated with a deceleration in biological aging.

Indexed as

AgingCardiovascular DiseasesEpigenesis, GeneticAdultAgedChinaCross-Sectional StudiesDNA MethylationEpigenomicsFemaleHumansMaleMiddle AgedRegistriesTwins, DizygoticTwins, MonozygoticCardiovascular healthEpigenetic clockLife’s essential 8Twin study

Identifiers

PMID41491280
PMCPMC12870025

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