ArticleNature medicine2026
A minimally invasive dried blood spot biomarker test for the detection of Alzheimer's disease pathology.
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Article in Nature medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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16citing papers in PubMed
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Who cites it
16 citing papers in PubMed.
- Rapid-Forming Conductive Antifouling Hydrogel Coating Enables Magnetically Guided Electrochemical POCT for Direct at‑Home Blood Testing.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Performance of upper-arm capillary blood collection for Alzheimer's disease and central nervous system biomarkers: comparison of Tasso+ and venous plasma.medRxiv : the preprint server for health sciences · 2026Article
- Progress in Optical Methods for the Detection of Two Core Blood Biomarkers of Alzheimer's Disease: Amyloid-Beta and Tau Proteins.Biosensors · 2026Review
- Overview in Electrochemical and Electrical Biosensors for Determining Blood Protein Biomarkers of Alzheimer's Disease.Biosensors · 2026Review
- Evaluation of Dried Plasma Spot-Based Quantification of Glial Fibrillary Acidic Protein as a Disease-Associated Biomarker in Neuromyelitis Optica Spectrum Disorder.Annals of clinical and translational neurology · 2026Article
- Validation of Plasma p-tau217 as a Biomarker of Prodromal Alzheimer's Disease.Revista de neurologia · 2026Article
- Radical-Mediated In Situ Fluorescence Dye Deposition: A Simple Interfacial Signal Amplification Reaction for Ultrasensitive Immunoassay on Barcode Beads.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Article
- Breaking barriers: Enhancing access to dementia clinical trials in the United Kingdom-Insights from the Scientific Advisory Board of the Dame Barbara Windsor Dementia Goals Programme.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Article
- Alzheimer's Disease blood biomarkers measured through remote capillary sampling correlate with cognition in older adults.Nature communications · 2026Article
- Advancing biomarker development for chronic traumatic encephalopathy: Summary and recommendations from the 2025 Leon Thal Summit.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Translational lipidomics reveals BMP and its precursor LPG as biomarkers for CLN5 Batten disease.bioRxiv : the preprint server for biology · 2026Article
- Dried blood spot 3-year stability suitability for biomarker discovery and biobanking initiatives in companion animals.PloS one · 2026Article
- Factors associated with phlebotomy failure in an Alzheimer's Disease Research Center cohort.Alzheimer's & dementia (New York, N. Y.)Article
- A scalable workflow using digital cognitive assessment and pTau217 for MCI detection.Alzheimer's & dementia (Amsterdam, Netherlands)Article
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Authors and funding
48 authors.
Hanna Huber *Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at the University of Gothenburg, Mölndal, Sweden.ORCID http://orcid.org/0009-0004-3080-6870
Laia Montoliu-Gaya *Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at the University of Gothenburg, Mölndal, Sweden.ORCID http://orcid.org/0000-0001-7684-6318
Wagner S Brum *Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at the University of Gothenburg, Mölndal, Sweden.ORCID http://orcid.org/0000-0002-9777-0559
Jakub VávraDepartment of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at the University of Gothenburg, Mölndal, Sweden.
Yara YakoubDepartment of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at the University of Gothenburg, Mölndal, Sweden.
Haley WeningerDepartment of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at the University of Gothenburg, Mölndal, Sweden.
Luisa Sophie Braun-WohlfahrtDepartment of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at the University of Gothenburg, Mölndal, Sweden.
Joel SimrénDepartment of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at the University of Gothenburg, Mölndal, Sweden.
Mercé BoadaAce Alzheimer Center Barcelona-Universitat Internacional de Catalunya, Barcelona, Spain.ORCID http://orcid.org/0000-0003-2617-3009
Agustín RuizAce Alzheimer Center Barcelona-Universitat Internacional de Catalunya, Barcelona, Spain.ORCID http://orcid.org/0000-0003-2633-2495
Amanda CanoAce Alzheimer Center Barcelona-Universitat Internacional de Catalunya, Barcelona, Spain.
Adelina OrellanaAce Alzheimer Center Barcelona-Universitat Internacional de Catalunya, Barcelona, Spain.
Sergi ValeroAce Alzheimer Center Barcelona-Universitat Internacional de Catalunya, Barcelona, Spain.
Laia CañadaAce Alzheimer Center Barcelona-Universitat Internacional de Catalunya, Barcelona, Spain.
Natalia TantinyaAce Alzheimer Center Barcelona-Universitat Internacional de Catalunya, Barcelona, Spain.
Ana Belen NogalesAce Alzheimer Center Barcelona-Universitat Internacional de Catalunya, Barcelona, Spain.
Pilar Sanz-CartagenaAce Alzheimer Center Barcelona-Universitat Internacional de Catalunya, Barcelona, Spain.
Anna DittrichDepartment of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at the University of Gothenburg, Mölndal, Sweden.ORCID http://orcid.org/0000-0002-5168-2975
Ingmar SkoogDepartment of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at the University of Gothenburg, Mölndal, Sweden.
Millie Sander-LongCollege of Medicine and Health, University of Exeter, Exeter, UK.
Clive BallardCollege of Medicine and Health, University of Exeter, Exeter, UK.ORCID http://orcid.org/0000-0003-0022-5632
Megan RichardsCollege of Medicine and Health, University of Exeter, Exeter, UK.
Mary O'LearyCollege of Medicine and Health, University of Exeter, Exeter, UK.
Frederikke Kragh ClemmensenDanish Dementia Research Centre, Department of Neurology, Copenhagen University Hospital - Rigshospitalet, Copenhagen, Denmark.ORCID http://orcid.org/0000-0001-7374-2919
Hannah H D WandallDanish Dementia Research Centre, Department of Neurology, Copenhagen University Hospital - Rigshospitalet, Copenhagen, Denmark.
Daniele AltomareDepartment of Clinical and Experimental Sciences, University of Brescia, Brescia, Italy.
Valentina CantoniDepartment of Clinical and Experimental Sciences, University of Brescia, Brescia, Italy.
Erik StomrudClinical Memory Research Unit, Department of Clinical Sciences Malmö, Lund University, Lund, Sweden.
Sebastian PalmqvistClinical Memory Research Unit, Department of Clinical Sciences Malmö, Lund University, Lund, Sweden.ORCID http://orcid.org/0000-0002-9267-1930
Alberto LleoSant Pau Memory Unit, Department of Neurology, Biomedical Research Institute Sant Pau, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain.ORCID http://orcid.org/0000-0002-2568-5478
Daniel AlcoleaSant Pau Memory Unit, Department of Neurology, Biomedical Research Institute Sant Pau, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain.ORCID http://orcid.org/0000-0002-3819-3245
Maria Carmona IraguiSant Pau Memory Unit, Department of Neurology, Biomedical Research Institute Sant Pau, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain.
Aida Sanjuan HernandezSant Pau Memory Unit, Department of Neurology, Biomedical Research Institute Sant Pau, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain.
Bessy BenejamSant Pau Memory Unit, Department of Neurology, Biomedical Research Institute Sant Pau, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain.
Laura Videla ToroSant Pau Memory Unit, Department of Neurology, Biomedical Research Institute Sant Pau, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain.ORCID http://orcid.org/0000-0002-9748-8465
Alpana SinghBanner Sun Health Research Institute, Sun City, AZ, USA.
Marisa N DenkingerBanner Sun Health Research Institute, Sun City, AZ, USA.
Anja Hviid SimonsenDanish Dementia Research Centre, Department of Neurology, Copenhagen University Hospital - Rigshospitalet, Copenhagen, Denmark.ORCID http://orcid.org/0000-0002-5461-162X
Silke KernDepartment of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at the University of Gothenburg, Mölndal, Sweden.
Anne CorbettCollege of Medicine and Health, University of Exeter, Exeter, UK.
Juan ForteaSant Pau Memory Unit, Department of Neurology, Biomedical Research Institute Sant Pau, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain.ORCID http://orcid.org/0000-0002-1340-638X
Lee HonigbergALZpath, Inc., Carlsbad, CA, USA.ORCID http://orcid.org/0000-0003-0996-1062
Barbara BorroniDepartment of Clinical and Experimental Sciences, University of Brescia, Brescia, Italy.ORCID http://orcid.org/0000-0001-9340-9814
Oskar HanssonClinical Memory Research Unit, Department of Clinical Sciences Malmö, Lund University, Lund, Sweden.ORCID http://orcid.org/0000-0001-8467-7286
Xavier MoratóAce Alzheimer Center Barcelona-Universitat Internacional de Catalunya, Barcelona, Spain.
Kaj BlennowDepartment of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at the University of Gothenburg, Mölndal, Sweden.ORCID http://orcid.org/0000-0002-1890-4193
Henrik ZetterbergDepartment of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at the University of Gothenburg, Mölndal, Sweden.ORCID http://orcid.org/0000-0003-3930-4354
Nicholas J AshtonDepartment of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at the University of Gothenburg, Mölndal, Sweden. Nicholas.Ashton@Bannerhealth.com.ORCID http://orcid.org/0000-0002-3579-8804
Funding
No grant is acknowledged in the PubMed record.
Abstract
Blood biomarkers have emerged as accurate tools for detecting Alzheimer's disease (AD) pathology, offering a minimally invasive alternative to traditional diagnostic methods such as imaging and cerebrospinal fluid (CSF) analysis. Yet, the logistics surrounding venipuncture for blood collection, although considerably simpler than the acquisition of imaging and CSF, require precise processing and storage specific to AD biomarkers that are still guided by medical personnel. Consequently, limitations in their widescale use in research and broader clinical implementation exist. The DROP-AD project investigates the potential of dried plasma spot (DPS) and dried blood spot (DBS) analysis, derived from capillary blood, for detecting AD biomarkers, including phosphorylated tau at amino acid 217 (p-tau217), glial fibrillary acidic protein and neurofilament light. Here, 337 participants from 7 centers were included, with 304 participants providing paired capillary DPS or DBS and venous plasma samples. We observed strong correlations between DPS p-tau217 and venous plasma p-tau217 (r
Indexed as
Alzheimer DiseaseBiomarkersDried Blood Spot TestingAgedAged, 80 and overFemaleGlial Fibrillary Acidic ProteinHumansMaleMiddle AgedNeurofilament ProteinsPhosphorylationtau ProteinsBiomarkersGlial Fibrillary Acidic ProteinMAPT protein, humanneurofilament protein LNeurofilament Proteinstau Proteins
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