ArticleEJNMMI physics2026
Assessing the feasibility of quantitative SPECT imaging for low
Article in EJNMMI physics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
- Normal Tissue Dosimetry of IntraperitonealJournal of nuclear medicine : official publication, Society of Nuclear Medicine · 2026Article
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Abstract
backgroundLead-212 (
methodsFillable phantom compartment shells of the kidneys, liver and five vertebrae (T11-L3) were 3D-printed based on a patient's CT-images. The same patient's [
resultsQuantification was relatively stable across energy windows and matrix sizes, but best results were achieved using 30-120 reconstruction updates. Low activity concentration volumes representing background and vertebral bodies (0.03-0.05 kBq/ml) were not quantifiable with deviations over 400% for all investigated reconstructions. The activity concentrations in the liver and kidneys were underestimated by 10-50% compared to the gamma counter measurements. Precision between SPECT acquisitions was higher for the larger image matrix, with standard deviations of liver and kidney measurements less than 6% for the higher activity images, and less than 8% for the lower activity images.
conclusionWe found that larger volumes, such as liver and kidneys with at least 210 Bq/ml, may be quantifiable with an accuracy of approx. 30-40%. While very low activity concentrations below 54 Bq/ml were not quantifiable, this still indicate carefully used imaging results to be of value in dosimetric calculations, also when characterising latter parts of time activity curves.
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