ArticleNeurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology2026
Effects of STN-DBS treatment on voice characteristics in patients with Parkinson's Disease.
Article in Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
objectiveTo evaluate the early changes of voice characteristics after deep brain stimulation (DBS) of subthalamic nucleus (STN) in patients with Parkinson's disease (PD) and to investigate the effect of the volume of tissue activated (VTA) of the STN on voice.
methodsFrom April 2024 to October 2024, 23 Parkinson's disease patients who underwent deep brain stimulation of subthalamic nucleus in Tianjin Huanhu Hospital and 22 healthy volunteers were collected. The voice characteristics of 23 Parkinson's disease patients without medication were evaluated preoperative, 3 months and 6 months after surgery. The voice handicap index (VHI) scale was used to evaluate the subjective voice function of patients. LingWAVES voice analysis software was used to collect patient and healthy control data and perform voice acoustic analysis. We further analyzed the correlation between postoperative tissue activation volume and voice characteristics.
resultsThe subjective VHI scores improved significantly at 3 months postoperatively (p = 0.025), but there was no significant difference at 6 months postoperatively (p = 0.283). The parameters including dysphonia severity index (DSI), fundamental frequency perturbation (Jitter) and amplitude perturbation (Shimmer) were significantly improved three and six months postoperatively compared with baseline (p < 0.05). There was a negative correlation between the improvement rate of DSI and the VTA overlap within limbic STN in the left hemisphere six months postoperatively (R2 = 0.4413, p < 0.001).
conclusionSTN-DBS can improve the voice characteristics of Parkinson's disease patients in the early stage after surgery, the improvement rate of DSI was negatively correlated with the VTA overlap within limbic STN in the left hemisphere.
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