Evidence map›Paper›PMID 41490731›Full record

ArticleJournal of Zhejiang University. Science. B2025

Drug-assisted synthesis of copper nanoparticles and their induction of cuproptosis and necrosis for breast cancer therapy.

Yuewen Wang, Jingjie Gao, Yuying Cheng, Hanling Pan, Hanxiao Tang, Chenguang Liu

Abstract read
In one paragraph

Article in Journal of Zhejiang University. Science. B, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Yuewen WangZhejiang Provincial Engineering Research Center of New Technologies and Applications for Targeted Therapy of Major Diseases, College of Life Sciences and Medicine, Zhejiang Sci-Tech University, Hangzhou 310018, China.
Jingjie GaoZhejiang Provincial Engineering Research Center of New Technologies and Applications for Targeted Therapy of Major Diseases, College of Life Sciences and Medicine, Zhejiang Sci-Tech University, Hangzhou 310018, China.
Yuying ChengZhejiang Provincial Engineering Research Center of New Technologies and Applications for Targeted Therapy of Major Diseases, College of Life Sciences and Medicine, Zhejiang Sci-Tech University, Hangzhou 310018, China.
Hanling PanZhejiang Provincial Engineering Research Center of New Technologies and Applications for Targeted Therapy of Major Diseases, College of Life Sciences and Medicine, Zhejiang Sci-Tech University, Hangzhou 310018, China.
Hanxiao TangAcademy of Chinese Medical Sciences, Henan University of Chinese Medicine, Zhengzhou 450046, China.
Chenguang LiuZhejiang Provincial Engineering Research Center of New Technologies and Applications for Targeted Therapy of Major Diseases, College of Life Sciences and Medicine, Zhejiang Sci-Tech University, Hangzhou 310018, China. cgliu@zstu.edu.cn.

Funding

the National Natural Science Foundation of China 32201092the Zhejiang Provincial Natural Science Foundation of China LTGY24H180008
6 · The paper itself

Abstract

Neurokinin-1 receptor (NK1R), a member of the G protein-coupled receptor (GPCR) family, contributes to multiple pathological processes, including pain, chronic inflammation, and cancer (Gutierrez et al., 2019; Robinson et al., 2023). Current reports and our previous work have proven that NK1R is highly expressed in many cancer cells, such as colorectal cancer and leukemia, and that targeted blocking of NK1R can effectively inhibit tumor cell proliferation (Li XQ et al., 2013; Li JY et al., 2016; Ge et al., 2019; Shi et al., 2021). In addition, GPCRs have been found not only in the plasma membrane but also in the membranes of endosomes and lysosomes with endocytosis (Irannejad et al., 2017; Yarwood et al., 2017), which is more pronounced in cancer cells with highly developed lysosomes (Ramírez-García et al., 2019).

Indexed as

Breast NeoplasmsCopperMetal NanoparticlesAnimalsCell Line, TumorFemaleHumansNecrosisReceptors, Neurokinin-1CopperReceptors, Neurokinin-1

Identifiers

PMID41490731
PMCPMC12768568

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.