ArticleEmerging infectious diseases2025
Retrospective Multicenter Study of Human Granulocytic Anaplasmosis, France, 2012-2024.
Article in Emerging infectious diseases, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Cardiovascular Complications of Anaplasmosis: A Case of Acute Pulmonary Embolism and Literature Review.Infectious disease reports · 2026Article
- Cerebrospinal Fluid Findings among Patients with Anaplasmosis and Central Nervous Involvement, Minnesota and Wisconsin, USA.Emerging infectious diseases · 2026Article
- Comparative Clinical Characteristics of ICU and Non-ICU Hospitalized Patients With Human Anaplasmosis.Open forum infectious diseases · 2026Article
- A Bayesian modelling framework for estimating tick-borne pathogen transmission dynamics at the host-tick interface.PLoS computational biology · 2026Article
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Authors and funding
11 authors.
Funding
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Abstract
Human granulocytic anaplasmosis (HGA), caused by Anaplasma phagocytophilum transmitted through tick bites, remains poorly documented in France. We conducted a retrospective, multicenter study of cases in Alsace during 2012-2024, including 39 HGA episodes in 38 patients PCR positive for A. phagocytophilum. Most (63.2%) patients were men, median age was 60.5 years, and 76.3% lived in rural areas. A tick bite was reported in 61.6% of cases. Frequent symptoms included fever (97.4%), fatigue (61.5%), and headache (61.5%). Laboratory findings showed elevated C-reactive protein (100%), thrombocytopenia (94.9%), leukopenia (59.0%), and cytolysis (66.7%). One patient had secondary hemophagocytic lymphohistiocytosis. Most (87.2%) patients were hospitalized; none required intensive care unit admission. Doxycycline was administered in 29 cases, and all patients recovered. HGA should be considered in febrile patients with recent tick exposure and cytopenia. Although often benign, rare severe HGA forms can occur and justify increased clinical awareness, especially in A. phagocytophilum-endemic areas.
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