ArticleBone & joint research2026
Cry2 prompts clock oscillation and temporomandibular joint homeostasis under mechanical loading.
Article in Bone & joint research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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9 authors.
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Abstract
Aims: Cartilage metabolism exhibits circadian rhythms (CR), and disruption of these often correlates with cartilage degeneration. Mechanical stimulation is a vital zeitgeber of CR in cartilage. However, the effects of mechanical loading on CR and cartilage homeostasis have not been explored. In this study, we aimed to explore the involvement of CR in mediating temporomandibular joint (TMJ) cartilage homeostasis under mechanical loading. Methods: We introduced the mechanical loading models of both rat TMJ chondrocytes and condyle explants. The mechanical loading was applied through rhythmic compression (12 hrs on and 12 hrs off), while the mechanical unloading model was set as control through static culture of cells and explants. Results: One-week static culture led to imbalanced cartilage metabolism and accelerated cartilage degeneration. This was accompanied by diminished levels of core clock genes ( Conclusion: This study elucidated the involvement of CR in mediating mechanical loading-related cartilage homeostasis, as well as the critical role of ROCK-actin-Cry2 in regulating normal CR and homeostasis of TMJ cartilage under rhythmic mechanical loading.
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