ArticleNano letters2026
Engineering a Mechanoresponsive DNA Origami Capsule for Drug Delivery to Narrowed Arteries.
Article in Nano letters, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Organ-on-chip (OoC) and nano-biomaterials: next generation of precision oral and dental healthcare research.Journal of nanobiotechnology · 2026Review
- Framework Nucleic Acids as a Nanocontainer for Delivering Heterogeneous Molecular Drugs.Pharmaceutics · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
Since their inception, DNA origami nanostructures (DONs) have attracted great interest for their programmable geometry, nanoscale precision, and biocompatibility. Here, we present mechanoresponsive DONs designed for targeted drug delivery to narrowed or obstructed arteries. Unlike conventional systems triggered by biochemical cues or external stimuli, our capsules respond autonomously to elevated local shear forces characteristic of stenotic blood flow. The design consists of a hollow boxlike structure sealed by two lids connected through flexible DNA springs, enabling mechanical opening under pathological flow conditions. The nanostructures were assembled and characterized by atomic force microscopy and cryo-transmission electron microscopy, and the mechanical response of the DNA springs was evaluated using optical tweezers. The results confirm that the capsules can operate within physiologically relevant force ranges, demonstrating their potential for noninvasive, site-specific drug release. This mechanoresponsive strategy offers a new paradigm for smart, force-activated nanocarriers for targeted diagnosis and therapy.
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Registered trials
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