Evidence map›Paper›PMID 41490425›Full record

ReviewMedical gas research2026

Hydrogen sulfide in precision medicine: connecting basic science, sensing, and clinical application.

Shuo Liu, Yao Li, Yingqian Zhang, Xingran Wang, Linhan Zhu

Abstract readReview
In one paragraph

Review in Medical gas research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. [Advances in the application of exhaled breath analysis technology in the detection and diagnosis of liver failure].Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology · 2026
    Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Shuo LiuHebei Key Laboratory of Advanced Laser Technology and Equipment, Center for Advanced Laser Technology, Hebei University of Technology, Tianjin, China.ORCID 0000-0002-3092-7638
Yao LiHebei Key Laboratory of Advanced Laser Technology and Equipment, Center for Advanced Laser Technology, Hebei University of Technology, Tianjin, China.
Yingqian ZhangDepartments of Respiration III, Hebei Children's Hospital, Shijiazhuang, Hebei Province, China.
Xingran WangHebei Key Laboratory of Advanced Laser Technology and Equipment, Center for Advanced Laser Technology, Hebei University of Technology, Tianjin, China.
Linhan ZhuDepartment of Pediatrics, Beijing Friendship Hospital, Capital Medical University, Beijing, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Hydrogen sulfide, as a critical endogenous gasotransmitter, plays a significant role in the pathophysiology of various diseases, including cardiovascular diseases, neurodegenerative disorders, respiratory dysfunctions, and cancer. The dynamic fluctuations in hydrogen sulfide concentration are closely associated with the onset and progression of these conditions. The precise monitoring of trace amounts of hydrogen sulfide in biological samples holds substantial value for elucidating disease mechanisms, developing diagnostic biomarkers, and enabling targeted therapies. This review provides a comprehensive overview of the current advancements in hydrogen sulfide detection technologies in medical applications, with a particular focus on the groundbreaking potential of novel spectroscopic techniques in medical diagnostics. This paper through an integrated research approach that bridges hydrogen sulfide biology, sensing technology, and clinical applications-particularly by utilizing breath and skin gas analysis as windows into metabolic and disease states. A core innovation presented in this work is the proposed optimization of the hydrogen sulfide-quartz-enhanced photoacoustic spectroscopy technique for medical settings, which provides a transformative tool for non-invasive disease screening, precise detection, and targeted therapeutic research. The ultimate goal is to bridge the gap between basic research, sensor technology, and clinical needs, driving innovative applications of hydrogen sulfide in precision medicine.

Indexed as

Hydrogen SulfidePrecision MedicineAnimalsHumansPhotoacoustic TechniquesHydrogen Sulfidebiomarkercancergasotransmitterhydrogen sulfidemetabolic diseaseneurologicalnon-invasive diagnosisQEPASrespiratorytrace gasesvascular

Identifiers

PMID41490425
PMCPMC12935137

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.