Evidence map›Paper›PMID 41490357›Full record

Observational studyPloS one2026

Evaluation of the first nutritional psychiatry and psychosomatics outpatient clinic: Protocol for a prospective study of an individualized biopsychosocial therapy approach.

Sabrina Mörkl, Anna Ramirez-Obermayer, Birgit DelFabro, Sonja Lackner, Sandra Holasek, Julia Traub, Katharina Größbacher, Andreas Brandstätter, Marilena Wilding, Jolana Wagner-Skacel

Registry-linked trialAbstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in PloS one, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07050342 (Evaluation Der Spezialambulanz Ernährung Und Psyche), which is not on this map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07050342 nanot yet recruitingnot on this map

Evaluation Der Spezialambulanz Ernährung Und Psyche: Eine Pilotstudie

TypeinterventionalSponsorMedical University of GrazRan2025 to 2028Enrolled84ConditionsPsychosomatic Disorders, Mental Health CareArmsPersonalized Nutrition-Based Psychosomatic Care
3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Sabrina MörklDepartment for Medical Psychology, Psychosomatics and Psychotherapy, Medical University of Graz, Graz, Steiermark, Austria.ORCID https://orcid.org/0000-0001-5034-6358
Anna Ramirez-ObermayerDepartment for Medical Psychology, Psychosomatics and Psychotherapy, Medical University of Graz, Graz, Steiermark, Austria.
Birgit DelFabroDepartment for Medical Psychology, Psychosomatics and Psychotherapy, Medical University of Graz, Graz, Steiermark, Austria.
Sonja LacknerDivision of Immunology, Medical University of Graz, Graz, Steiermark, Austria.ORCID https://orcid.org/0000-0002-5002-4460
Sandra HolasekDivision of Immunology, Medical University of Graz, Graz, Steiermark, Austria.
Julia TraubDepartment of Internal Medicine, Joint Facilities, Medical University of Graz, Graz, Steiermark, Austria.ORCID https://orcid.org/0000-0001-6984-9748
Katharina GrößbacherDepartment for Medical Psychology, Psychosomatics and Psychotherapy, Medical University of Graz, Graz, Steiermark, Austria.
Andreas BrandstätterDepartment for Medical Psychology, Psychosomatics and Psychotherapy, Medical University of Graz, Graz, Steiermark, Austria.
Marilena WildingDepartment for Medical Psychology, Psychosomatics and Psychotherapy, Medical University of Graz, Graz, Steiermark, Austria.ORCID https://orcid.org/0000-0001-9022-2296
Jolana Wagner-SkacelDepartment for Medical Psychology, Psychosomatics and Psychotherapy, Medical University of Graz, Graz, Steiermark, Austria.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPsychiatric and psychosomatic conditions are prevalent, disabling, and frequently resistant to standard treatments. Nutrition-focused care represents an emerging integrative approach, but clinical evidence remains scarce. The outpatient department for Nutritional Psychiatry and Nutritional Psychosomatics (NP) at the Medical University of Graz was established as a pilot project, offering add-on therapy with targeted nutritional counseling, nutrient substitution and supplementation, and interventions aiming to improve the gut-brain axis.

methodsThis prospective, monocentric, observational study will include approximately 84 new patients aged 18-65 over a 12-month period. Participants will complete online questionnaires at baseline and every 3 months, while routine blood samples will assess inflammatory and metabolic markers. The primary outcome is change in perceived stress, measured by the Perceived Stress Scale (PSS-10). Secondary outcomes include resilience, quality of life (SF-12, EQ-5D-5L), somatic symptoms (SSS-8), dietary habits (REAP-S v.2), psychodynamic structure (OPD-SFK), patient satisfaction, health literacy, and biomarker changes. DISCUSSION: This study will provide the first systematic evaluation of a specialized outpatient clinic for Nutritional Psychiatry and Psychosomatics in Europe. Findings will inform the potential of nutrition-focused interventions as part of routine psychiatric and psychosomatic care and may contribute to the development of personalized, integrative treatment strategies.

trial registrationClinicalTrials.gov NCT07050342 This study was prospectively registered at ClinicalTrials.gov (Identifier: NCT07050342), register date: 2025-06-24.

Indexed as

Psychophysiologic DisordersPsychosomatic MedicineAdolescentAdultAgedAmbulatory Care FacilitiesFemaleHumansMaleMiddle AgedNutrition TherapyPilot ProjectsPrecision MedicineProspective StudiesPsychiatryQuality of Life

Identifiers

PMID41490357
PMCPMC12768340

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.