ReviewBrain : a journal of neurology2026
The nociceptor primary cilium.
Review in Brain : a journal of neurology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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0 citing papers in PubMed.
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Authors and funding
6 authors.
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Abstract
The primary cilium, a single microtubule-based organelle protruding from the surface of cells, uses intraflagellar transport to establish and maintain its structure and function. It is well-established to guide development and function of the nervous system through signalling pathways identified by expression of molecular markers such as ADP-ribosylation factor-like protein 13 (ARL13B) and type 3 adenylyl cyclase (AC3). Its dysregulation results in ciliopathies, clinical syndromes affecting a broad range of organ systems. Recently, it has been established in several species that nociceptors have a primary cilium, which regulates their excitability, contributing to acute and chronic pain. Since primary cilium-dependent signalling, such as Hedgehog (Hh) and Wingless (Wnt) pathways, have been implicated in nociceptor excitability and pain syndromes, interventions targeting this organelle may provide novel treatments for pain.
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