ArticlePloS one2026
MedNeXt for accurate medical image classification and segmentation: A lightweight transformer-style convolutional neural network.
Article in PloS one, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Transformer-based deep learning architectures have achieved notable success across various medical image analysis tasks, driven by the global modeling capabilities of the self-attention mechanism. However, Transformer-based methods exhibit significant computational complexity and a large number of parameters, rendering them challenging to apply effectively in practical medical scenarios. Compared with Transformers, large-kernel Convolutional Neural Networks (CNNs) and Multi-Layer Perceptrons (MLPs) offer more efficient inference while retaining global contextual awareness. Therefore, we rethink the role of large-kernel CNNs and MLPs in medical image analysis and leverage them to replace the heavy self-attention operation, to strike a better balance between performance and efficiency. Specifically, we propose backbone models for medical image classification and segmentation, featured by three lightweight modules: Linear Attention Feed Forward Network (FFN) for enhancing lesion features, Spatial Encoding Module for integrating multi-scale lesion information, and Smooth Depth-Wise Convolution (DwConv) FFN for efficient interaction of channel features. Composed solely of lightweight convolutional and MLP operations, our method achieves a better balance between performance and efficiency, validated by the superior performances on five datasets with varying data scales and diseases, with 98.39% on SARS-COV2-CT-Scan, 98.12% on Monkeypox Skin Lesion Dataset, 98.58% on Large COVID-19-CT scan slice, 79.45% on Synapse and 91.28% on ACDC. The low computational cost, high-performance with limited training data, and generalizability to various of medical tasks make the proposed method a promising and practical solution for medical image classification and segmentation.
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