ArticlePloS one2026
Cold plasma-induced transcriptomic reprogramming and alternative splicing in tomato plants infected with ToBRFV.
Article in PloS one, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
3 citing papers in PubMed.
- Transcriptomic and alternative splicing reprogramming by low-dose gamma irradiation in tomato under ToBRFV infection.Biochemistry and biophysics reports · 2026Article
- Transcriptomic changes in tomato brown rugose fruit virus-infected tomato in response to low-dose gamma irradiation.Scientific reports · 2026Article
- Transcriptome SNP analysis of tomato seedlings exposed to low‑dose gamma irradiation and cold plasma suggests antiviral responses.Scientific reports · 2026Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cold atmospheric plasma (CAP), specifically cold air glow discharge plasma (CAGDP), offers a novel approach to enhancing plant defense against viral infections. This study investigates the effects of CAGDP on alternative splicing (AS) and transcriptome-wide gene expression in tomato seedlings infected with Tomato brown rugose fruit virus (ToBRFV). Using high-throughput RNA sequencing and bioinformatics analyses via CLC Genomics Workbench, custom Python scripts, and functional enrichment tools including STRING database and KEGG REST API, we identified significant AS changes, predominantly exon skipping and intron retention, in chromosomes associated with disease resistance. These splicing alterations were linked to key biological processes such as metabolic pathways, catalytic activity, and hormone signaling. Moreover, integration of miRNA-mRNA networks predicted by psRNATarget and visualized in Cytoscape revealed a complex regulatory system involving both transcriptional and post-transcriptional mechanisms. The identification of 19 differentially expressed AS genes highlights the coordinated reprogramming induced by CAGDP to activate antiviral defenses. These findings highlight cold plasma technology as a promising, eco-friendly tool to reprogram plant molecular pathways and enhance resistance to viral pathogens.
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Registered trials
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