Trial reportGastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association2026
Indocyanine green fluorescence-guided proximal margin identification in laparoscopic distal gastrectomy: a randomized clinical trial.
Trial report in Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Indocyanine green-guided lymphadenectomy and survival of patients with gastric cancer: a systematic review and meta-analysis of time-to-event data.Surgical endoscopy · 2026Review
- Carbon nanoparticles-guided margin identification and lymphadenectomy in laparoscopic distal gastrectomy for gastric cancer: a propensity score-matched study.Surgical endoscopy · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors.
Funding
Abstract
backgroundAchieving negative resection margins is critical in GC surgery, yet intraoperative tumor localization remains challenging, particularly in minimally invasive approaches such as LDG. This study was conducted to evaluate the safety, feasibility, and efficacy of indocyanine green (ICG) fluorescence imaging for real-time margin identification during laparoscopic distal gastrectomy (LDG) for gastric cancer (GC).
methodsThis randomized clinical trial included 422 patients with GC (cT1-4a, N0/+, M0) between September 2019 and December 2021, who underwent LDG with or without ICG fluorescence guidance. Oncological and perioperative outcomes were compared between the groups.
resultsThe ICG group demonstrated a significantly lower rate of positive initial proximal margins (0% vs. 5.5%, P < 0.001) and reduced the need for total gastrectomy in middle third gastric cancer (0.5% vs. 3.8%, P = 0.037). In our study cohort, ICG guidance standardized resection margins (median 5.0 cm, IQR 3.8–5.6) with fewer deviations from guideline recommendations (P = 0.018). Pathological analysis confirmed the absence of tumor cells beyond 4 cm from the gross margin in our study cohort. The ICG group also had shorter operation times (217.60 ± 31.11 vs. 225.48 ± 27.69 min, P = 0.008) and fewer pulmonary complications (3.0% vs. 8.0%, P = 0.046). At 3-year follow-up, no significant survival difference was observed (DFS: 74.4% vs. 68.7%, P = 0.220; OS: 82.4% vs. 79.4%, P = 0.437).
conclusionsICG fluorescence imaging improved margin accuracy, reduced non-indicated total gastrectomies, and enhanced operative efficiency. Its application in LDG provides a potential standardized strategy for achieving R0 resection.
Indexed as
Identifiers
41489800What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.