Evidence map›Paper›PMID 41489653›Full record

ArticleEuropean journal of nuclear medicine and molecular imaging2026

Aortic valve calcium score from computed tomography for signal localization by cardiac amyloid radionuclide imaging to predict aortic stenosis and assess prognosis in patients with transthyretin cardiomyopathy.

Guillaume Bonnans, Philippe Blanc, Eve Cariou, Rémi Engel, Damien Legallois, Hugo Malerbi, Stéphanie Cazalbou, Yoan Lavie-Badie, Emmanuelle Cassol, Marie Beaurain and 4 more

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Article in European journal of nuclear medicine and molecular imaging, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Guillaume BonnansDepartment of Cardiology and Referral Center for Cardiomyopathies, Cardiac Imaging Center, Toulouse University Hospital, University of Toulouse, 1, Avenue Jean Poulhès, TSA 50032, Toulouse Cedex 9, 31059, Toulouse, France.
Philippe BlancDepartment of Nuclear Medicine, Albi Hospital, Albi, France.
Eve CariouDepartment of Cardiology and Referral Center for Cardiomyopathies, Cardiac Imaging Center, Toulouse University Hospital, University of Toulouse, 1, Avenue Jean Poulhès, TSA 50032, Toulouse Cedex 9, 31059, Toulouse, France.
Rémi EngelDepartment of Nephrology and Referral Center for Rare Diseases, Toulouse University Hospital, University of Toulouse, Toulouse, France.
Damien LegalloisDepartment of Cardiology, Normandie Univ, UNICAEN, Inserm U1086 ANTICIPE, Caen Normandie University Hospital, Caen, France.
Hugo MalerbiDepartment of Cardiology and Referral Center for Cardiomyopathies, Cardiac Imaging Center, Toulouse University Hospital, University of Toulouse, 1, Avenue Jean Poulhès, TSA 50032, Toulouse Cedex 9, 31059, Toulouse, France.
Stéphanie CazalbouDepartment of Cardiology and Referral Center for Cardiomyopathies, Cardiac Imaging Center, Toulouse University Hospital, University of Toulouse, 1, Avenue Jean Poulhès, TSA 50032, Toulouse Cedex 9, 31059, Toulouse, France.
Yoan Lavie-BadieDepartment of Cardiology and Referral Center for Cardiomyopathies, Cardiac Imaging Center, Toulouse University Hospital, University of Toulouse, 1, Avenue Jean Poulhès, TSA 50032, Toulouse Cedex 9, 31059, Toulouse, France.
Emmanuelle CassolDepartment of Nuclear Medicine, Cardiac Imaging Center, Toulouse University Hospital, University of Toulouse, Toulouse, France.
Marie BeaurainDepartment of Nuclear Medicine, Albi Hospital, Albi, France.
Pauline FournierDepartment of Cardiology and Referral Center for Cardiomyopathies, Cardiac Imaging Center, Toulouse University Hospital, University of Toulouse, 1, Avenue Jean Poulhès, TSA 50032, Toulouse Cedex 9, 31059, Toulouse, France.
Alain ManriqueDepartment of Nuclear Medicine, Normandie Univ, Caen Normandie University Hospital, Caen, France.
Olivier LairezDepartment of Cardiology and Referral Center for Cardiomyopathies, Cardiac Imaging Center, Toulouse University Hospital, University of Toulouse, 1, Avenue Jean Poulhès, TSA 50032, Toulouse Cedex 9, 31059, Toulouse, France. lairez.o@chu-toulouse.fr.ORCID 0000-0001-8141-6582
Toulouse Amyloidosis Research Network collaborators

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTransthyretin cardiomyopathy (ATTR-CM) and aortic stenosis (AS) are frequently associated. The diagnosis of ATTR-CM can be made by performing a cardiac amyloid radionuclide imaging (CARI) with a computed tomography (CT) scan to localize the signal, which allows visualization aortic valve calcifications (AVC). The aim of this study was to determine whether AVC on the CT performed at the time of the CARI for the diagnosis of ATTR-CM were predictive of AS and had an impact on prognosis.

methodsCT images of patients diagnosed with ATTR-CM by CARI were reviewed for the presence of AVC and the calcium score was calculated. A three-stage visual score for AVC was developed (score 0, absence; score 1, < 50% of the annulus; score 2, ≥ 50% of the annulus). AVC were then compared with the aortic valve hemodynamic parameters by echocardiography.

results263 patients were included. AVC were present in 153 (58%) patients. The median calcium score was 430 [200–1140]. A cut-off calcium score value ≥ 380 predicted an AS with a sensitivity of 91% and a specificity of 81%. For severe AS, a threshold of ≥ 1690 yielded an area under the curve of 0,98 (95%CI: 0.95–1.00, P < 0.0001). A visual score of 2 predicted severe AS with 94% sensitivity and 90% specificity. After multivariate analysis, both the aortic valve calcium score and visual score were independent predictors of all-cause mortality.

conclusionAortic valve calcium score and semi-quantitative visual score are predictors of AS severity and mortality.

Indexed as

Amyloid Neuropathies, FamilialAortic ValveAortic Valve StenosisCalcinosisCalciumCardiomyopathiesTomography, X-Ray ComputedAgedAged, 80 and overFemaleHumansMalePrognosisRadionuclide ImagingRetrospective StudiesCalciumAortic stenosisAortic valve calcificationsBone scintigraphyCardiac amyloidosisSingle photon emission tomographyTransthyretin cardiomyopathy

Identifiers

PMID41489653

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.