Evidence map›Paper›PMID 41489464›Full record

ArticleNucleus (Austin, Tex.)2026

Transcriptional profiling of Hutchinson-Gilford progeria patients identifies primary target pathways of progerin.

Sandra Vidak, Sohyoung Kim, Tom Misteli

Abstract read
In one paragraph

Article in Nucleus (Austin, Tex.), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors.

Sandra VidakCell Biology of Genomes, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.ORCID 0000-0001-7579-8545
Sohyoung KimHormone Action and Oncogenesis Section, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.
Tom MisteliCell Biology of Genomes, National Cancer Institute, National Institutes of Health, Bethesda, MD, USA.ORCID 0000-0003-3530-3020

Funding

Nuclear Architecture and DiseaseZIABC010309 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI MISTELI, THOMAS A · 2009 to 2025
$39.8M
Intramural NIH HHS ZIA BC010309
6 · The paper itself

Abstract

Hutchinson Gilford Progeria Syndrome (HGPS) is an ultra-rare pediatric premature aging disorder. It is caused by a point mutation in the

Indexed as

Gene Expression ProfilingLamin Type AProgeriaAnimalsHumansMiceSignal TransductionTranscriptomeUnfolded Protein ResponseLamin Type Aprelamin AHutchinson-Gilford progeria syndromepathway analysisprogerinRNA-seqtranscriptional profiling

Identifiers

PMID41489464
PMCPMC12773485

What OpenQuestion holds

Textmetadata
LicenceCC0
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.