VANTAGE: van-based real-time HIV sequencing for transmission mapping and drug resistance profiling in war-affected Ukraine.

Ganna Kovalenko, Mariia G Liulchuk, Myroslava Filippovych, Pavlo Smyrnov, Steffanie A Strathdee, Tetyana I Vasylyeva

Abstract read

In one paragraph

Article in AIDS (London, England), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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4 · The record

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5 · Who and what money

Authors and funding

6 authors.

Ganna KovalenkoDepartment of Population Health and Disease Prevention, Joe C. Wen School of Population and Public Health, University of California, Irvine, Irvine, CA, USA.

Mariia G LiulchukState Institution "L.V. Gromashevsky Institute of Epidemiology and Infectious Diseases of the National Academy of Medical Sciences of Ukraine".

Myroslava FilippovychAlliance for Public Health, Kyiv, Ukraine.

Pavlo SmyrnovAlliance for Public Health, Kyiv, Ukraine.

Steffanie A StrathdeeDivision of Infectious Diseases and Global Public Health, University of California San Diego, La Jolla, CA, USA.

Tetyana I VasylyevaDepartment of Population Health and Disease Prevention, Joe C. Wen School of Population and Public Health, University of California, Irvine, Irvine, CA, USA.

Funding

Social network disruption, stigma, and HIV transmission and care dynamics among forcibly displaced MSM in UkraineR01DA057141 · NIDA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Tetyana Vasylyeva · 2023 to 2026

$2.4M

NIDA NIH HHS R01 DA057141

6 · The paper itself

Abstract

We deployed the VANTAGE (VAN for Transmissible Agent Genomic Epidemiology) mobile system in Lviv, Ukraine, demonstrating end-to-end sequencing of dried blood spot samples within a clinic van usually serving de-occupied and frontline regions. HIV-1 pol sequences were obtained from 50% of samples, all subtype A6. Median time to 100× coverage was 38 min. Phylogenetic analysis revealed a local transmission cluster including a displaced person and the non-nucleoside reverse transcriptase inhibitor (NNRTI) resistance mutation E138A, supporting real-time HIV genomic surveillance in humanitarian crises.

Indexed as

Drug Resistance, ViralHIV-1HIV InfectionsMobile Health UnitsGenotypeHumansMaleMolecular EpidemiologyPhylogenypol Gene Products, Human Immunodeficiency VirusSequence Analysis, DNAUkrainepol Gene Products, Human Immunodeficiency Virus

Identifiers

PMID41489325

DOI10.1097/QAD.0000000000004360

PMCPMC13189857

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.