Evidence map›Paper›PMID 41489320›Full record

ArticleCNS neuroscience & therapeutics2026

Differences in the Efficacy of Cognitive Function Treatment Related to Functional Patterns in the Frontal-Limbic Network in Patients With Bipolar Disorder.

Sujuan Li, Yangpan Ou, Haiping Liu, Qianyu Dong, Yan Qiu, Ziwei Teng, Hui Tang, Hui Xiang, Guowei Wu, Jindong Chen and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in CNS neuroscience & therapeutics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Sujuan LiDepartment of Psychiatry, National Clinical Research Center for Mental Disorders, and National Center for Mental Disorders, The Second Xiangya Hospital of Central South University, Changsha, Hunan, China.
Yangpan OuDepartment of Psychiatry, National Clinical Research Center for Mental Disorders, and National Center for Mental Disorders, The Second Xiangya Hospital of Central South University, Changsha, Hunan, China.ORCID 0009-0007-0691-8057
Haiping LiuQingdao Mental Health Center, Qingdao, Shandong, China.
Qianyu DongDepartment of Psychiatry, National Clinical Research Center for Mental Disorders, and National Center for Mental Disorders, The Second Xiangya Hospital of Central South University, Changsha, Hunan, China.
Yan QiuXiamen Xianyue Hospital, Xianyue Hospital Affiliated With Xiamen Medical College, Fujian Psychiatric Center, Fujian Clinical Research Center for Mental Disorders, Xiamen, Fujian, China.
Ziwei TengDepartment of Psychiatry, Clinical Research Center for Depressive Disorder in Hunan Province, The Second People's Hospital of Hunan Province (Brain Hospital of Hunan Province), Changsha, China.
Hui TangDepartment of Psychiatry, National Clinical Research Center for Mental Disorders, and National Center for Mental Disorders, The Second Xiangya Hospital of Central South University, Changsha, Hunan, China.
Hui XiangDepartment of Psychiatry, National Clinical Research Center for Mental Disorders, and National Center for Mental Disorders, The Second Xiangya Hospital of Central South University, Changsha, Hunan, China.
Guowei WuDepartment of Psychiatry, National Clinical Research Center for Mental Disorders, and National Center for Mental Disorders, The Second Xiangya Hospital of Central South University, Changsha, Hunan, China.
Jindong ChenDepartment of Psychiatry, National Clinical Research Center for Mental Disorders, and National Center for Mental Disorders, The Second Xiangya Hospital of Central South University, Changsha, Hunan, China.
Bolun WangDepartment of Radiology, The Second Xiangya Hospital of Central South University, Clinical Research Center for Medical Imaging in Hunan Province, Scientific Research Program of Hunan Provincial Health Commission, Changsha, Hunan, China.
Lutao JiangThe Third People's Hospital of Tongren, Tongren, Guizhou, China.
Haishan WuDepartment of Psychiatry, National Clinical Research Center for Mental Disorders, and National Center for Mental Disorders, The Second Xiangya Hospital of Central South University, Changsha, Hunan, China.ORCID 0000-0002-6571-7024

Funding

Joint Funding Project of Hunan Provincial Natural Science Foundation 2024JJ9109Joint Funding Project of Hunan Provincial Natural Science Foundation 2025JJ90282National Natural Science Foundation of China 82271571the China Postdoctoral Science Foundation 2025M772098
6 · The paper itself

Abstract

backgroundThis study aimed to identify neurobiomarkers that predict the efficacy of treatment of cognition in patients with bipolar disorder (BD).

methodsRegional homogeneity (ReHo) and degree centrality (DC) values, which are two functional magnetic resonance imaging indicators, were analyzed to compare differences in brain activities between patients with BD and healthy controls (HC).

resultsBD patients (N = 92) exhibited increased activity in the right hippocampus or right parahippocampal gyrus compared to HC, while their ReHo and DC values in the left middle frontal gyrus decreased in the resting state. The delayed memory scores were predicted by using connectome-based predictive modeling in patients with BD at baseline. After 12 weeks of treatment, the patients with BD, whose cognitive function improved (n = 24), showed activity in the right superior temporal gyrus (STG) and left anterior cingulate cortex (ACC) at baseline. The improvement in cognitive function of patients with BD is distinguished by abnormal activities using support vector machine analysis.

conclusionsThe abnormal frontal-limbic network plays a critical role in the underlying neuropathological mechanism of cognitive impairment in patients with BD. The right STG and left ACC hold the potential to serve as neurobiomarkers for predicting the clinical efficacy of cognitive function treatment. These regions provide additional target options for future physical treatments of cognitive impairment in patients with BD.

Indexed as

Bipolar DisorderCognitionFrontal LobeLimbic SystemNerve NetAdultConnectomeFemaleHumansMagnetic Resonance ImagingMaleMiddle AgedTreatment Outcomeconnectome‐based predictive modelingdegree centralityregional homogeneityrepeatable battery for the assessment of neuropsychological statussupport vector machine

Identifiers

PMID41489320
PMCPMC12766901

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.