ArticleJournal of natural products2026
Total Synthesis and Structural Revision of Keenamide A.
Article in Journal of natural products, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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1 citing paper in PubMed.
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7 authors.
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Abstract
Stereochemical assignments of thiazoline-containing cyanobactins, a family of ribosomally synthesized and post-translationally modified peptides, are often complicated due to the propensity of the exomethine and C-4 chiral centers of thiazolines to epimerize under basic and acidic conditions. In this work, we re-evaluate the proposed configuration of the leucine-thiazoline moiety of the cyanobactin-like cyclopeptide keenamide A. Using a fast and adaptable strategy for the synthesis of thiazoline-containing cyclopeptides, we synthesized four possible keenamide A stereoisomers, one of which was oxidized to mollamide C, the thiazole analogue of keenamide A. Comparison of the NMR spectra of synthetic keenamide A stereoisomers with that of natural keenamide A combined with X-ray crystallographic analysis indicates that the originally proposed (
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