Evidence map›Paper›PMID 41488894›Full record

ArticleFrontiers in pediatrics2025

Protocol for the efficacy and safety of fecal microbiota transplantation in children with autism spectrum disorder: a prospective single-center, single-arm interventional study.

Baixian Lin, Zhongsheng Zhu, Xiao Yang, Ziyuan Li, Haokui Zhou, Mingjing Luo, Jiaojie Guan, Yigui Zou, Hu Chen, Zeling Zhuang and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in pediatrics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Baixian Lin *International Medical Center, Endoscopy Center and Gastroenterology Department, Shenzhen Children's Hospital, Shantou University Medical College, Shenzhen, China.
Zhongsheng Zhu *International Medical Center, Endoscopy Center and Gastroenterology Department, Shenzhen Children's Hospital, Shantou University Medical College, Shenzhen, China.
Xiao YangState Key Laboratory of Quantitative Synthetic Biology, Shenzhen Institute of Synthetic Biology, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China.
Ziyuan LiInternational Medical Center, Endoscopy Center and Gastroenterology Department, Shenzhen Children's Hospital, Shantou University Medical College, Shenzhen, China.
Haokui ZhouState Key Laboratory of Quantitative Synthetic Biology, Shenzhen Institute of Synthetic Biology, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China.
Mingjing LuoState Key Laboratory of Quantitative Synthetic Biology, Shenzhen Institute of Synthetic Biology, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China.
Jiaojie GuanState Key Laboratory of Quantitative Synthetic Biology, Shenzhen Institute of Synthetic Biology, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China.
Yigui ZouInternational Medical Center, Endoscopy Center and Gastroenterology Department, Shenzhen Children's Hospital, Shantou University Medical College, Shenzhen, China.
Hu ChenInternational Medical Center, Endoscopy Center and Gastroenterology Department, Shenzhen Children's Hospital, Shantou University Medical College, Shenzhen, China.
Zeling ZhuangInternational Medical Center, Endoscopy Center and Gastroenterology Department, Shenzhen Children's Hospital, Shantou University Medical College, Shenzhen, China.
Shiyun MengInternational Medical Center, Endoscopy Center and Gastroenterology Department, Shenzhen Children's Hospital, Shantou University Medical College, Shenzhen, China.
Wenwen LiInternational Medical Center, Endoscopy Center and Gastroenterology Department, Shenzhen Children's Hospital, Shantou University Medical College, Shenzhen, China.
Qinghua YangInternational Medical Center, Endoscopy Center and Gastroenterology Department, Shenzhen Children's Hospital, Shantou University Medical College, Shenzhen, China.
Dongling DaiInternational Medical Center, Endoscopy Center and Gastroenterology Department, Shenzhen Children's Hospital, Shantou University Medical College, Shenzhen, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Autism spectrum disorder (ASD) is a neurodevelopmental condition affecting 0.7% of children globally, with 90% experiencing comorbid gastrointestinal (GI) symptoms. Fecal microbiota transplantation (FMT) may modulate ASD symptoms via the microbiota-gut-brain axis (MGBA). Methods: This open-label single-arm trial enrolls 30 children (2-12 years) with moderate-to-severe ASD, defined as a Childhood Autism Rating Scale (CARS) score of ≥36. Participants receive 3 nasojejunal FMTs (5 mL/kg) over 5 days. The primary outcomes are GI symptom improvement, assessed using the Gastrointestinal Symptom Rating Scale (GSRS), and ASD severity, assessed using the CARS. Secondary outcomes include social responsiveness (Social Responsiveness Scale, SRS), aberrant behaviors (Aberrant Behavior Checklist, ABC), and gut microbiota changes assessed by metagenomic next-generation sequencing (mNGS). Ethics and dissemination: Ethical approval obtained from Shenzhen Children's Hospital Ethics Committee. Results will be disseminated via peer-reviewed publications and conference presentations.

Indexed as

autism spectrum disorderclinical protocolfecal microbiota transplantationgastrointestinal symptomsmicrobiomemicrobiota dysbiosismicrobiota-gut-brain axis

Identifiers

PMID41488894
PMCPMC12757332

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.