Evidence map›Paper›PMID 41488854›Full record

ArticleAnnals of gastroenterological surgery2026

Outcomes of Resected Cases of Pancreatic Ductal Adenocarcinoma Patients With Unexpected Postoperative Uncovering Noncurative Factors: A Multicenter Retrospective Study.

Hiroto Matsui, Naoki Ikenaga, Masafumi Nakamura, Takaaki Tatsuguchi, Shingo Kozono, Hirohisa Okabe, Hiromitsu Hayashi, Tomohiko Adachi, Susumu Eguchi, Kazuaki Hashimoto and 11 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Annals of gastroenterological surgery, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors.

Hiroto MatsuiDepartment of Gastroenterological, Breast and Endocrine Surgery Yamaguchi University Graduate School of Medicine Ube Yamaguchi Japan.ORCID https://orcid.org/0000-0003-3588-8751
Naoki IkenagaDepartment of Surgery and Oncology Kyushu University Fukuoka Japan.
Masafumi NakamuraDepartment of Surgery and Oncology Kyushu University Fukuoka Japan.
Takaaki TatsuguchiDepartment of Surgery Kitakyushu Municipal Medical Center Fukuoka Japan.ORCID https://orcid.org/0000-0002-4156-4991
Shingo KozonoDepartment of Surgery Kitakyushu Municipal Medical Center Fukuoka Japan.
Hirohisa OkabeDepartment of Gastroenterological Surgery Kumamoto University Kumamoto Japan.
Hiromitsu HayashiDepartment of Gastroenterological Surgery Kumamoto University Kumamoto Japan.ORCID https://orcid.org/0000-0002-1832-4287
Tomohiko AdachiDepartment of Surgery Nagasaki University Graduate School of Biomedical Sciences Nagasaki Japan.ORCID https://orcid.org/0000-0001-7025-6173
Susumu EguchiDepartment of Surgery Nagasaki University Graduate School of Biomedical Sciences Nagasaki Japan.ORCID https://orcid.org/0000-0002-7876-0152
Kazuaki HashimotoDepartment of Surgery Kurume University School of Medicine Kurume Japan.
Toru HisakaDepartment of Surgery Kurume University School of Medicine Kurume Japan.
Takao IdeDepartment of Surgery, Faculty of Medicine Saga University Saga Japan.ORCID https://orcid.org/0000-0003-2441-4438
Hirokazu NoshiroDepartment of Surgery, Faculty of Medicine Saga University Saga Japan.ORCID https://orcid.org/0000-0003-3227-7816
Teijiro HirashitaDepartment of Gastroenterological and Pediatric Surgery, Faculty of Medicine Oita University Oita Japan.ORCID https://orcid.org/0000-0002-0252-0494
Atsushi MiyoshiDepartment of Surgery Saga Medical Center Koseikan Saga Japan.ORCID https://orcid.org/0000-0001-7500-7459
Atsushi NanashimaDepartment of Surgery, Faculty of Medicine University of Miyazaki Miyazaki Japan.ORCID https://orcid.org/0000-0002-3246-557X
Masatoshi KajiwaraDepartment of Gastroenterological Surgery, Faculty of Medicine Fukuoka University Fukuoka Japan.
Tomoharu YoshizumiDepartment of Surgery and Science, Graduate School of Medical Sciences Kyushu University Fukuoka Japan.ORCID https://orcid.org/0000-0002-4497-1816
Yasuhisa MoriDepartment of Surgery 1, School of Medicine University of Occupational and Environmental Health Kitakyushu Japan.ORCID https://orcid.org/0000-0001-9928-3933
Hiroaki NaganoDepartment of Gastroenterological, Breast and Endocrine Surgery Yamaguchi University Graduate School of Medicine Ube Yamaguchi Japan.ORCID https://orcid.org/0000-0002-7074-3315
Kyushu Study Group of Treatment for Pancreatobilliary Cancer

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Aim: We aimed to refine treatment strategies for resected cases of pancreatic ductal adenocarcinoma in patients with unexpectedly uncovered postoperative noncurative factors while also evaluating the effectiveness of neoadjuvant and adjuvant chemotherapy. Methods: We retrospectively analyzed clinicopathological and follow-up data from 1068 PDAC patients who underwent surgical resection at 13 Kyushu Study Group institutions (January 2016-December 2020). Patients were categorized into two groups: without (Group A) or with (Group B) unexpected postoperative noncurative factors. Kaplan-Meier analysis assessed disease-free and overall survival, while univariate and multivariate analyses using the Cox proportional hazards model identified prognostic factors. Results: Group B ( Conclusion: Cases with noncurative factors had significantly poorer prognoses than those without. In the present study, effective adjuvant chemotherapy for these patients could not be demonstrated. Therefore, thorough preoperative and intraoperative evaluation of noncurative factors is crucial to prevent futile surgery.

Indexed as

adjuvant chemotherapyfrailtygeriatric oncologypancreatic ductal adenocarcinomaradial resection

Identifiers

PMID41488854
PMCPMC12757158

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.