ArticleAnnals of gastroenterological surgery2026
Prolonged Prophylactic Antibiotics Based on Preoperative Bile Culture Reduce Surgical Site Infections After Pancreaticoduodenectomy Following Preoperative Biliary Drainage: A Propensity-Matched Analysis.
Article in Annals of gastroenterological surgery, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Objective: The optimum duration of prophylactic antibiotics after pancreaticoduodenectomy following preoperative biliary drainage to prevent surgical site infections remains controversial. We evaluate whether a prolonged course of prophylactic antibiotics reduces surgical site infection after pancreaticoduodenectomy following biliary drainage more than that within the standard duration. Methods: We enrolled 352 consecutive patients from one hospital who underwent pancreaticoduodenectomy following biliary drainage between 2010 and 2023. The patients were prospectively assigned to two groups according to prophylactic antibiotic duration. In the standard duration group (2010-2013; 112 patients), the duration was within 24 h postoperatively. In the prolonged duration group (2014-2023; 240 patients), it was 3 days postoperatively. The primary endpoint was the incidence of surgical site infection between these groups. We performed 1:1 propensity score matching to balance baseline characteristics, which yielded 77 patients per group. Results: There was significantly less surgical site infection in the longer duration group (13%) than in the standard duration group (29%) ( Conclusions: Prolonged prophylactic antibiotics significantly reduced surgical site infection incidence after pancreaticoduodenectomy in patients undergoing preoperative biliary drainage.
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