Evidence map›Paper›PMID 41488802›Full record

ArticlePhysics and imaging in radiation oncology2025

Microstructural modelling based on diffusion weighted imaging to guide dose painting in carbon ions for large sacral chordomas.

Giovanni Parrella, Letizia Morelli, Giuseppe Magro, Lars Glimelius, Jakob Ödén, Mario Ciocca, Sara Imparato, Marco Rotondi, Maria Rosaria Fiore, Ester Orlandi and 3 more

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Article in Physics and imaging in radiation oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Giovanni ParrellaPolitecnico di Milano, Department of Electronics, Information and Bioengineering, Milano, Italy.
Letizia MorelliPolitecnico di Milano, Department of Electronics, Information and Bioengineering, Milano, Italy.
Giuseppe MagroCentro Nazionale di Adroterapia Oncologica, Clinical Unit, Pavia, Italy.
Lars GlimeliusRaySearch Laboratories, Eugeniavӓgen 18, 113 68, Stockholm, Sweden.
Jakob ÖdénRaySearch Laboratories, Eugeniavӓgen 18, 113 68, Stockholm, Sweden.
Mario CioccaCentro Nazionale di Adroterapia Oncologica, Clinical Unit, Pavia, Italy.
Sara ImparatoCentro Nazionale di Adroterapia Oncologica, Clinical Unit, Pavia, Italy.
Marco RotondiCentro Nazionale di Adroterapia Oncologica, Clinical Unit, Pavia, Italy.
Maria Rosaria FioreCentro Nazionale di Adroterapia Oncologica, Clinical Unit, Pavia, Italy.
Ester OrlandiCentro Nazionale di Adroterapia Oncologica, Clinical Unit, Pavia, Italy.
Guido BaroniPolitecnico di Milano, Department of Electronics, Information and Bioengineering, Milano, Italy.
Silvia MolinelliCentro Nazionale di Adroterapia Oncologica, Clinical Unit, Pavia, Italy.
Chiara PaganelliPolitecnico di Milano, Department of Electronics, Information and Bioengineering, Milano, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background and purpose: Dose Painting (DP) in radiotherapy is a strategy to account for the tumor microstructural heterogeneity. This study evaluated a DP approach in carbon ion radiotherapy (CIRT), using cell count estimates derived from diffusion-weighted magnetic resonance imaging (DWI). Materials and methods: Thirty-seven large sacral chordoma (SC) patients were analysed. Voxel-wise cell count was estimated from DWI using a published microstructural model. A Poisson-based tumor control probability (TCP) model, fitted on 27 patients, guided DP optimization in a research version of RayStation 2024A. The approach was tested on 10 patients, comparing uniform-dose plans against two strategies: dose redistribution (DR), which maintained the mean gross tumor volume (GTV) dose, and dose escalation (DE), which allowed a 3 % increase. Plan evaluation on targets and organs at risk (OARs) included dose-volume histogram metrics (D Results: DE and DR plans met clinical acceptability criteria. DE increased TCP from 75.5 ± 5.6 % to 83.3 ± 3.9 % (p < 0.001), with -3 to +5 percentage points variation under uncertainty. DR plans showed a TCP gain of 1.8 ± 1.0 percentage points. No significant dose or LET Conclusions: Dose painting based on microstructural modelling in CIRT showed potential to improve TCP while sparing OARs.

Indexed as

Carbon ionsDiffusion MRIDose paintingMicrostructural modelSacral chordomasTCP

Identifiers

PMID41488802
PMCPMC12756709

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.