ArticleiScience2026
Age-dependent immune responses and resident cell dynamics in young mice following pneumonia.
Sylvia N Michki, Javier V Perez, Dharma A Varapula, Aaron J Thomas, Tiffaney L Vincent, Benjamin D Singer, Jarod A Zepp, Sharon A McGrath-Morrow
Abstract read
In one paragraphArticle in iScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
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3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
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4 · The recordCorrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what moneyAuthors and funding
8 authors.
Sylvia N MichkiChildren's Hospital of Philadelphia Division of Pulmonary and Sleep Medicine, Philadelphia, PA 19104, USA.
Javier V PerezChildren's Hospital of Philadelphia Division of Pulmonary and Sleep Medicine, Philadelphia, PA 19104, USA.
Dharma A VarapulaChildren's Hospital of Philadelphia Division of Pulmonary and Sleep Medicine, Philadelphia, PA 19104, USA.
Aaron J ThomasChildren's Hospital of Philadelphia Division of Pulmonary and Sleep Medicine, Philadelphia, PA 19104, USA.
Tiffaney L VincentChildren's Hospital of Philadelphia Division of Pulmonary and Sleep Medicine, Philadelphia, PA 19104, USA.
Benjamin D SingerDivision of Pulmonary and Critical Care Medicine, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.
Jarod A ZeppChildren's Hospital of Philadelphia Division of Pulmonary and Sleep Medicine, Philadelphia, PA 19104, USA.
Sharon A McGrath-MorrowChildren's Hospital of Philadelphia Division of Pulmonary and Sleep Medicine, Philadelphia, PA 19104, USA.
Funding
Tissue resident macrophages regulate proteostasis in the aging lungP01AG049665 · NIA · NORTHWESTERN UNIVERSITY AT CHICAGO · PI NAVDEEP S CHANDEL · 2015 to 2026
$26.9MThe Cell Phenotyping and Mouse CoreP01HL154998 · NHLBI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI KAREN M RIDGE · 2021 to 2026
$18.9MMechanisms of regulatory T cell-mediated recovery from severe viral pneumoniaR01HL149883 · NHLBI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI Benjamin David Singer · 2020 to 2026
$4.1MResolution of Diffuse Inflammatory Lung Injury in Neonatal MiceR01HL114800 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI MCGRATH-MORROW, SHARON ANN · 2013 to 2021
$3.3MLung repair mechanisms mediated by the immune-fibroblast interfaceR35GM146835 · NIGMS · CHILDREN'S HOSP OF PHILADELPHIA · PI Jarod Zepp · 2022 to 2026
$2.2MEpigenetic modifiers of regulatory T cell function following viral pneumoniaR01HL153122 · NHLBI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI SINGER, BENJAMIN DAVID · 2021 to 2021
$63kNHLBI NIH HHS P01 HL154998NHLBI NIH HHS R01 HL114800NHLBI NIH HHS R01 HL149883NHLBI NIH HHS R01 HL153122NIA NIH HHS P01 AG049665NIGMS NIH HHS R35 GM146835
6 · The paper itselfAbstract
Infancy represents a unique period of immune vulnerability. This study investigated age-specific immune dynamics associated with differential health outcomes in the immature lung. Single-cell RNA sequencing (scRNA-seq) and bulk RNA sequencing were employed to comprehensively map the transcriptional landscapes of lung-resident cells. Marked differences in gene expression and cell-type distributions were observed between neonates and juveniles. Acute inflammatory responses in neonatal lungs were associated with decreased alveolar epithelial type 2 (AT2) cell proliferation, as well as a transient disruption of ligand-receptor interactions (
Indexed as
immune responseimmunologytranscriptomics
Identifiers
PMID41488789
PMCPMC12757541
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