Evidence map›Paper›PMID 41488784›Full record

ArticleiScience2026

A human 3D culture-organ-on-chip platform for investigating the tumor microenvironment response to ionizing radiation.

Jerome Lacombe, Sean E Dunn, Marie Layac, Maria Soldevila, Nabhan M Fakrudin, Brett Duane, Kurt Chen, Matthew W Barrett, James Helton, Evagelia C Laiakis and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Jerome LacombeCenter for Applied NanoBioscience and Medicine, College of Medicine Phoenix, University of Arizona, 475 North 5th Street, Phoenix, AZ 85004, USA.
Sean E DunnCenter for Applied NanoBioscience and Medicine, College of Medicine Phoenix, University of Arizona, 475 North 5th Street, Phoenix, AZ 85004, USA.
Marie LayacCenter for Applied NanoBioscience and Medicine, College of Medicine Phoenix, University of Arizona, 475 North 5th Street, Phoenix, AZ 85004, USA.
Maria SoldevilaCenter for Applied NanoBioscience and Medicine, College of Medicine Phoenix, University of Arizona, 475 North 5th Street, Phoenix, AZ 85004, USA.
Nabhan M FakrudinCenter for Applied NanoBioscience and Medicine, College of Medicine Phoenix, University of Arizona, 475 North 5th Street, Phoenix, AZ 85004, USA.
Brett DuaneCenter for Applied NanoBioscience and Medicine, College of Medicine Phoenix, University of Arizona, 475 North 5th Street, Phoenix, AZ 85004, USA.
Kurt ChenCenter for Applied NanoBioscience and Medicine, College of Medicine Phoenix, University of Arizona, 475 North 5th Street, Phoenix, AZ 85004, USA.
Matthew W BarrettCenter for Applied NanoBioscience and Medicine, College of Medicine Phoenix, University of Arizona, 475 North 5th Street, Phoenix, AZ 85004, USA.
James HeltonCenter for Applied NanoBioscience and Medicine, College of Medicine Phoenix, University of Arizona, 475 North 5th Street, Phoenix, AZ 85004, USA.
Evagelia C LaiakisDepartment of Radiation Medicine, Georgetown University Medical Center, 3970 Reservoir Rd NW, Washington DC 20057, USA.
Albert J FornaceDepartment of Radiation Medicine, Georgetown University Medical Center, 3970 Reservoir Rd NW, Washington DC 20057, USA.
Shyam JaniDignity Health Cancer Institute at St. Joseph's Hospital and Medical Center, 625 N 6th St, Phoenix, AZ 85004, USA.
Stephen SorensenDignity Health Cancer Institute at St. Joseph's Hospital and Medical Center, 625 N 6th St, Phoenix, AZ 85004, USA.
Shunjiro FunakiMitsubishi Gas Chemical Company, Inc., Tokyo, Japan.
Aidnag DiazDignity Health Cancer Institute at St. Joseph's Hospital and Medical Center, 625 N 6th St, Phoenix, AZ 85004, USA.
Frederic ZenhausernCenter for Applied NanoBioscience and Medicine, College of Medicine Phoenix, University of Arizona, 475 North 5th Street, Phoenix, AZ 85004, USA.

Funding

Tissue Culture Shared ResourceP30CA051008 · NCI · GEORGETOWN UNIVERSITY · PI MARCUS S NOEL · 1990 to 2026
$71.5M
Targeted Biomarker Panels and Pre-processing Device for the Rapid Assessment of Radiation Injury in Easily Accessible BiofluidsU01AI148307 · NIAID · GEORGETOWN UNIVERSITY · PI LAIAKIS, EVAGELIA CHRISTOS, ZENHAUSERN, FREDERIC · 2021 to 2025
$2.9M
NCI NIH HHS P30 CA051008NIAID NIH HHS U01 AI148307
6 · The paper itself

Abstract

Studying complex human responses, such as radiation-induced effects in the tumor microenvironment (TME), requires advanced

Indexed as

BiotechnologyCancer systems biologyCell biologyImmunology

Identifiers

PMID41488784
PMCPMC12757608

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.