Evidence map›Paper›PMID 41488782›Full record

ArticleiScience2026

High-grade serous ovarian cancer induced in different sites of origin in mice exemplifies diverse features of the human disease.

Ludmila Szabova, Lucy Lu, Melanie B Gordon, Kristine Johnson, Theresa M Guerin, Laura Bassel, Deborah B Householder, Margalie Edouard, Amy Ries, Serguei Kozlov and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Ludmila SzabovaCenter for Advanced Preclinical Research, Laboratory Animal Sciences Program, Frederick National Laboratory for Cancer Research, Frederick, MD 21072, USA.
Lucy LuCenter for Advanced Preclinical Research, National Cancer Institute, National Institutes of Health, Frederick, MD 21072, USA.
Melanie B GordonCenter for Advanced Preclinical Research, Laboratory Animal Sciences Program, Frederick National Laboratory for Cancer Research, Frederick, MD 21072, USA.
Kristine JohnsonCenter for Advanced Preclinical Research, Laboratory Animal Sciences Program, Frederick National Laboratory for Cancer Research, Frederick, MD 21072, USA.
Theresa M GuerinCenter for Advanced Preclinical Research, Laboratory Animal Sciences Program, Frederick National Laboratory for Cancer Research, Frederick, MD 21072, USA.
Laura BasselCenter for Advanced Preclinical Research, Laboratory Animal Sciences Program, Frederick National Laboratory for Cancer Research, Frederick, MD 21072, USA.
Deborah B HouseholderCenter for Advanced Preclinical Research, National Cancer Institute, National Institutes of Health, Frederick, MD 21072, USA.
Margalie EdouardCenter for Advanced Preclinical Research, Laboratory Animal Sciences Program, Frederick National Laboratory for Cancer Research, Frederick, MD 21072, USA.
Amy RiesCenter for Advanced Preclinical Research, Laboratory Animal Sciences Program, Frederick National Laboratory for Cancer Research, Frederick, MD 21072, USA.
Serguei KozlovCenter for Advanced Preclinical Research, Laboratory Animal Sciences Program, Frederick National Laboratory for Cancer Research, Frederick, MD 21072, USA.
N Keith CollinsCenter for Advanced Preclinical Research, National Cancer Institute, National Institutes of Health, Frederick, MD 21072, USA.
Wendi CusterCenter for Advanced Preclinical Research, Laboratory Animal Sciences Program, Frederick National Laboratory for Cancer Research, Frederick, MD 21072, USA.
Kathleen ChoDepartment of Pathology, University of Michigan Medical School, Ann Arbor, MI 48109, USA.
Goli SamimiDivision of Cancer Prevention, National Cancer Institute, National Institutes of Health, Rockville, MD 20850, USA.
Robert H ShoemakerDivision of Cancer Prevention, National Cancer Institute, National Institutes of Health, Rockville, MD 20850, USA.
Zoe Weaver OhlerCenter for Advanced Preclinical Research, Laboratory Animal Sciences Program, Frederick National Laboratory for Cancer Research, Frederick, MD 21072, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Preclinical mouse models for ovarian cancer that faithfully recapitulate human disease on both histopathological and molecular levels are crucial for advancing novel interventions into the clinic. We developed three genetically engineered mouse (GEM) models for fallopian tube-originating ovarian cancer with the loss of Brca1, Trp53, and Rb expression driven by

Indexed as

Biological sciences research methodologiesCancerModel organism

Identifiers

PMID41488782
PMCPMC12757576

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.